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1263285-52-4

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1263285-52-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1263285-52-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,3,2,8 and 5 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1263285-52:
(9*1)+(8*2)+(7*6)+(6*3)+(5*2)+(4*8)+(3*5)+(2*5)+(1*2)=154
154 % 10 = 4
So 1263285-52-4 is a valid CAS Registry Number.

1263285-52-4Downstream Products

1263285-52-4Relevant articles and documents

Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors

Liu, Kevin K.C.,Huang, Xiaojun,Bagrodia, Shubha,Chen, Jeffrey H.,Greasley, Samantha,Cheng, Hengmiao,Sun, Shaoxian,Knighton, Dan,Rodgers, Caroline,Rafidi, Kristina,Zou, Aihua,Xiao, Jiezhan,Yan, Shengyong

, p. 1270 - 1274 (2011/04/16)

Intra-molecular hydrogen bonding was introduced to the quinazoline motif to form a pseudo ring (intra-molecular H-bond scaffold, iMHBS) to mimic our previous published core structures, pyrido[2.3-D]pyrimidin-7-one and pteridinone, as PI3K/mTOR dual inhibitors. This design results in potent PI3K/mTOR dual inhibitors and the purposed intra-molecular hydrogen bonding structure is well supported by co-crystal structure in PI3Kγ enzyme. In addition, a novel synthetic route was developed for these analogs.

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