1263296-80-5

Usage

Uses

Used in Pharmaceutical Industry:
2-DiphenylMethyl-2-azaspiro[3.3]hept-5-one is used as a key intermediate for the synthesis of angular spirocyclic azetidines. These azetidines serve as valuable building blocks in drug discovery, contributing to the development of novel therapeutic agents with potential applications in various medical conditions.

Upstream product

• 40320-60-3 N-benzhydryl 3-azetidinone 
• 1263296-79-2 6-benzhydryl-6-aza-8-oxa-dispiro[2.0.3.1]octane 

Downstream Products

• 1263296-81-6 2-benzhydryl-2-azaspiro[3.3]heptan-5-ol 
• 1263296-92-9 2-benzhydryl-2-azaspiro[3.3]heptan-5-one oxime 
• 1263296-82-7 (R,S)-2-benzhydryl-2-azaspiro[3.3]heptan-5-amine 
• 1263296-83-8 2-benzhydryl-2-azaspiro[3.3]heptane-5-carbaldehyde 
• 1263296-85-0 (R,S)-methyl 2-benzhydryl-2-azaspiro[3.3]heptane-5-carboxylate 
• 1581684-02-7 (S)-2-benzhydryl-2-azaspiro[3.3]heptan-5-amine 
• 1581684-03-8 tert-butyl (S)-(2-benzhydryl-2-azaspiro[3.3]heptan-5-yl)carbamate 
• 1581684-04-9 tert-butyl (S)-(2-azaspiro[3.3]heptan-5-yl)carbamate 
• 1581684-01-6 (S)-N-((S)-2-benzhydryl-2-azaspiro[3.3]heptan-5-yl)-2-methylpropane-2-sulfinamide 

Relevant academic research and scientific papers

TRICYCLIC GYRASE INHIBITORS FOR USE AS ANTIBACTERIAL AGENTS

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

Synthesis of novel angular spirocyclic azetidines

The syntheses of a variety of novel angular azaspiro[3.3]heptanes are reported. gem-Difluoro and gem-dimethyl variants of the angular 1,6-diazaspiro[3.3]heptane module were prepared in high yields using efficient sequences. Additionally, a practical one-p