2-DiphenylMethyl-2-azaspiro[3.3]hept-5-one

Base Information

• Chemical Name: 2-DiphenylMethyl-2-azaspiro[3.3]hept-5-one
• CAS No.: 1263296-80-5
• Molecular Formula: C19H19NO
• Molecular Weight: 277.366
• Hs Code.: 2933990090
• Mol file: 1263296-80-5.mol

Synonyms:2-DiphenylMethyl-2-azaspiro[3.3]hept-5-one;2-Benzhydryl-2-azaspiro[3.3]heptan-5-one;2-Azaspiro[3.3]heptan-5-one, 2-(diphenylmethyl)-

Chemical Property of 2-DiphenylMethyl-2-azaspiro[3.3]hept-5-one

Chemical Property:

• Melting Point: 120-122 °C
• Boiling Point: 416.2±35.0 °C(Predicted)
• PKA: 6.73±0.20(Predicted)
• PSA: 20.31000
• Density: 1.19±0.1 g/cm3(Predicted)
• LogP: 3.37880
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Diphenylmethyl-2-azaspiro[3.3]heptan-5-one ^*data from reagent suppliers

Safty Information:

• Hazard Codes: N
• Statements: 50

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Diphenylmethyl-2-azaspiro[3.3]heptan-5-one is a useful intermediate for the preparation of angular spirocyclic azetidines which functions as building blocks for drug discovery.

Technology Process of 2-DiphenylMethyl-2-azaspiro[3.3]hept-5-one

There total 3 articles about 2-DiphenylMethyl-2-azaspiro[3.3]hept-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

N-benzhydryl 3-azetidinone (40320-60-3) + 2-methylcyclopropyldiphenylsulfonium trifluomethanesulfonate → 6-(diphenylmethyl)-6-azaspiro[3.3]heptan-1-one (1263296-80-5)

Guidance literature:

2-methylcyclopropyldiphenylsulfonium trifluomethanesulfonate; With potassium hexamethylsilazane; In tetrahydrofuran; at -70 ℃; for 0.5h; Inert atmosphere;

N-benzhydryl 3-azetidinone; In tetrahydrofuran; at -40 ℃; for 4h;

With lithium iodide; In tetrahydrofuran; at 20 - 50 ℃;

Reference yield:

6-benzhydryl-6-aza-8-oxa-dispiro[2.0.3.1]octane (1263296-79-2) → 6-(diphenylmethyl)-6-azaspiro[3.3]heptan-1-one (1263296-80-5)

Guidance literature:

With lithium iodide; In tetrahydrofuran; toluene; at 20 - 50 ℃; for 15h; Inert atmosphere;

DOI:10.1021/ol103050c

Reference yield:

N-benzhydryl 3-azetidinone (40320-60-3) → 6-(diphenylmethyl)-6-azaspiro[3.3]heptan-1-one (1263296-80-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.08 h / -40 °C / Inert atmosphere

1.2: 4 h / -40 °C / Inert atmosphere

2.1: lithium iodide / tetrahydrofuran; toluene / 15 h / 20 - 50 °C / Inert atmosphere

With potassium hexamethylsilazane; lithium iodide; In tetrahydrofuran; toluene;

DOI:10.1021/ol103050c

upstream raw materials:

6-benzhydryl-6-aza-8-oxa-dispiro[2.0.3.1]octane

N-benzhydryl 3-azetidinone

Downstream raw materials:

2-benzhydryl-2-azaspiro[3.3]heptan-5-ol

2-benzhydryl-2-azaspiro[3.3]heptan-5-one oxime

(R,S)-2-benzhydryl-2-azaspiro[3.3]heptan-5-amine

2-benzhydryl-2-azaspiro[3.3]heptane-5-carbaldehyde

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