126331-36-0Relevant academic research and scientific papers
Synthesis of 1,3-Disubstituted-pyrroloisoquinoline-2-carboxylic Acids, Esters and Amides
Bridge, Andrew W.,Fenton, Garry,Halley, Frank,Hursthouse, Michael B.,Lehmann, Christian W.,Lythgoe, David J.
, p. 2761 - 2772 (2007/10/02)
A number of 1,3-disubstituted pyrroloisoquinoline-2-carboxylic esters have been prepared using a variety of independent routes.The corresponding acids and a range of amides were subsequently synthesised.The primary amides were found to differ significantly from those reported to arise from the reaction between the anion of an isoquinoline Reissert compound and an α,β-unsaturated nitrile.Re-investigation has established that the latter reaction does not produce primary amides.The true nature of the products as 2-acyl-3-aminopyrroloisoquinolines was established using X-ray crystallography.
Pyrroloisoquinolines useful as hypercholesterolemic and hyperlipoprotienimic agents
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, (2008/06/13)
Pyrrolo[2,1-a]isoquinoline derivatives of the formula: STR1 wherein R1 and R2 each represent cycloalkyl or alkyl, alkenyl or alkynyl which may be halogen-substituted, or optionally substituted aryl or heteroaryl, X represents ethylen
