1263313-09-2

Basic information

• Product Name: 2,2-Dimethyl-1-[4-(trifluoromethoxy)phenyl]propan-1-one
• Synonyms: 2,2-Dimethyl-1-[4-(trifluoromethoxy)phenyl]propan-1-one;t-Butyl 4-(trifluoromethoxy)phenyl ketone
• CAS NO: 1263313-09-2
• Molecular Formula: C₁₂H₁₃F₃O₂
• Molecular Weight: 246.2256296
• Mol File: 1263313-09-2.mol

Chemical Properties

• Boiling Point: 260.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.167±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2,2-Dimethyl-1-[4-(trifluoromethoxy)phenyl]propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dimethyl-1-[4-(trifluoromethoxy)phenyl]propan-1-one(1263313-09-2)
• EPA Substance Registry System: 2,2-Dimethyl-1-[4-(trifluoromethoxy)phenyl]propan-1-one(1263313-09-2)

Safety Data

• Hazardous Substances Data: 1263313-09-2(Hazardous Substances Data)

Upstream product

• 659-28-9 p-trifluoromethoxybenzaldehyde 
• 84379-72-6 1,3-dioxoisoindolin-2-yl 3,3-dimethylbutanoate 

Downstream Products

• 1263313-21-8 4-chloro-N-[2-(2,2-dimethyl-propionyl)-5-trifluoromethoxy-phenyl]-benzenesulfonamide 

Relevant articles and documents

N-Heterocyclic Carbene-Catalyzed Decarboxylative Alkylation of Aldehydes

We found that N-heterocyclic carbene catalysis promoted the unprecedented decarboxylative coupling of aryl aldehydes and tertiary or secondary alkyl carboxylic acid-derived redox-active esters to produce aryl alkyl ketones. The mild and transition-metal-free reaction conditions are attractive features of this method. The power of this protocol was demonstrated by the functionalization of pharmaceutical drugs and natural product. A reaction pathway involving single electron transfer from an enolate form of Breslow intermediate to a redox ester followed by recombination of the resultant radical pair to form a carbon-carbon bond is proposed.