1263314-74-4Relevant articles and documents
Monofluoroalkenylation of Dimethylamino Compounds through Radical–Radical Cross-Coupling
Xie, Jin,Yu, Jintao,Rudolph, Matthias,Rominger, Frank,Hashmi, A. Stephen K.
, p. 9416 - 9421 (2016)
An unprecedented and challenging radical–radical cross-coupling of α-aminoalkyl radicals with monofluoroalkenyl radicals derived from gem-difluoroalkenes was achieved. This first example of tandem C(sp3)?H and C(sp2)?F bond functionalization through visible-light photoredox catalysis offers a facile and flexible access to privileged tetrasubstituted monofluoroalkenes under very mild reaction conditions. The striking features of this redox-neutral method in terms of scope, functional-group tolerance, and regioselectivity are illustrated by the late-stage fluoroalkenylation of complex molecular architectures such as bioactive (+)-diltiazem, rosiglitazone, dihydroartemisinin, oleanic acid, and androsterone derivatives, which represent important new α-amino C?H monofluoroalkenylations.
