1263322-08-2Relevant academic research and scientific papers
Asymmetric Total Synthesis and Evaluation of Antitumor Activity of Ophiorrhisine A and Its Derivatives
Onozawa, Tadayoshi,Kitajima, Mariko,Kogure, Noriyuki,Takayama, Hiromitsu
, p. 15312 - 15322 (2018)
The first asymmetric total synthesis of ophiorrhisine A (1), a new cyclic tetrapeptide isolated from Ophiorrhiza nutans, was accomplished via an intramolecular aromatic nucleophilic substitution reaction (IMSNAr) of a linear tripeptide to construct a 14-membered paracyclophane ring, resulting in confirmation of its structure and absolute configuration. The structure-activity relationship study of 1 and its derivatives demonstrated that some derivatives possessed cytotoxicity toward human cancer cell lines A549, HT29, and HCT116.
A new family of cinchona-derived amino phosphine precatalysts: Application to the highly enantio- and diastereoselective silver-catalyzed isocyanoacetate aldol reaction
Sladojevich, Filippo,Trabocchi, Andrea,Guarna, Antonio,Dixon, Darren J.
supporting information; experimental part, p. 1710 - 1713 (2011/04/15)
A new class of readily accessible chiral amino-phosphine precatalysts derived from 9-amino(9-deoxy) epicinchona alkaloids has been developed. In combination with Ag(I) salts, these amino-phosphines performed as effective cooperative Brnsted base/Lewis aci
