126334-85-8

Upstream product

• 638-07-3 ethyl (2-chloroaceto)acetate 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 

Downstream Products

• 133389-79-4 3-carbethoxy-6-chloro-2-dichloromethyl-4-phenylquinoline 
• 1226918-04-2 ethyl 6-chloro-2-((4-chloro-2-methoxyphenoxy)methyl)-4-phenylquinoline-3-carboxylate 
• 1226918-05-3 ethyl 6-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)-4-phenylquinoline-3-carboxylate 
• 1203506-52-8 ethyl 6-chloro-2-[(2S)-2-(hydroxymethyl)tetrahydro-1H-1-pyrrolyl]methyl-4-phenyl-3-quinolinecarboxylate 
• 1203506-55-1 ethyl 2-[((3aR,5R,6S,6aR)-5-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylperhydrofuro[2,3-d][1,3]dioxol-6-yloxy)methyl]-6-chloro-4-phenyl-3-quinolinecarboxylate 
• 1203506-53-9 ethyl 2-[4-(tert-butoxycarbonyl)piperazino]methyl-6-chloro-4-phenyl-3-quinolinecarboxylate 
• 1203506-57-3 2-[(1S)-1-benzyl-2-hydroxyethyl]-7-chloro-9-phenyl-2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-one 
• 1335025-22-3 2-(2-chlorobenzylaminomethyl)-6-chloro-4-phenylquinoline-3-carboxylic acid 
• 1335025-21-2 2-(benzylaminomethyl)-6-chloro-4-phenylquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

Convenient and efficient method for the synthesis of substituted quinolines via one-pot heteroannulation reaction of o-amino arylketones with α-methylene ketones under solvent-free conditions

A facile and practical approach to the synthesis of a wide range of functionalized quinolines was developed via a tandem heteroannulation reaction of o-aminoarylketones with diverse α-methylene ketones in high yields by using tetrabutylammonium peroxydisu

Synthesis and antibacterial activity of substituted quinoline derivatives

An efficient and convenient method is reported for the synthesis of various substituted quinolines through the condensation of o-amino aryl carbonyls with ketones containing an active methylene group in the presence of CuSO4·5H2O as

Friedlaender synthesis of polysubstituted quinolines and naphthyridines promoted by propylphosphonic anhydride (T3P) under mild conditions

A new convenient, efficient and environmentally eco-friendly protocol for Friedlaender synthesis of polysubstituted quinolines and naphthyridines is described. A wide variety of new products were readily prepared in the presence of propylphosphonic anhydride (T3P) in short reaction times and excellent yields under mild conditions. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2012.

1-butyl-3-methylimidazolium hydrogen sulfate ([bmim]-HSO 4)-mediated synthesis of polysubstituted quinolines

In this research, polysubstituted quinolines are prepared from the reaction of 2-aminobenzophenones and ethylacetoacetate or ketones in the presence of 1-butyl-3-methylimidazolium hydrogen sulfate [bmim]HSO4 as an acidic ionic liquid in good to

Synthesis, trypanocidal activity and molecular modeling studies of 2-alkylaminomethylquinoline derivatives

Research and development of new drugs effective in the treatment of Trypanosoma cruzi infections are a real need for the 16 million people infected in the Americas. In a previous work, a quinoline derivative substituted by a 2-piperidylmethyl moiety showe

Diversity-oriented synthesis of quinolines via Friedlaender annulation reaction under mild catalytic conditions

An efficient and practical method has been manifested for the diversity-oriented synthesis of quinolines via Friedlaender annulation reaction for the generation of a wide range of structurally interesting and pharmacologically significant compounds by using eerie ammonium, nitrate as a catalyst (10 mol %) at ambient temperature in 45 min, A variety of functional groups are introduced at various positions of the quinoline moiety, and further the diversity of the core skeleton was expanded at R1 and R 2 positions by the synthesis of various hybrids. Initial screening of the compounds for cytotoxicity against a series of cancer cell lines showed promising results.

SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS

The present invention relates to sodium channel inhibitors of Formula (I): in which R1, R2, R3, R4, R5, X, Y, and Z are as defined herein, and to their use in the treatment of various disease states,

Synthesis of 6-chloroquinolines using benzyltrimethylammonium tetrachloroiodate as a selective chlorinating agent and an efficient generator of HCl

A simple and efficient one-pot synthesis of 6-chloroquinolines was achieved in good yields via the three-component reaction of 2-aminoaryl ketones, α-methylene carbonyl compounds, and BTMA ICl4 in AcOH.

Microwave-assisted Friedl?nder synthesis of quinolines derivatives as potential antiparasitic agents

A series of substituted quinolines was developed via the Friedl?nder reaction employing microwave irradiation (MW), in the presence of a catalytic amount of hydrochloric acid. The products were obtained in good yields in 1.5-12 min and were tested in vitr