126338-77-0

Usage

Uses

Used in Wound Healing:
Miramistin is used as an antimicrobial component for the treatment of infected wounds of various genesis. It plays an important role in solving the problem of wound healing by providing powerful antimicrobial action without the side effects associated with antibiotics.
Used in Drug Delivery Systems:
Miramistin is used as a stabilizing agent for silver nanoparticles, which are employed in various drug delivery applications. This enhances the delivery, bioavailability, and therapeutic outcomes of the drugs.
Used in Antimicrobial Applications:
Miramistin is used as an antimicrobial component in the innovative substance of Chitosan-Miramistin Complex (CMC), which is effective against a wide range of microorganisms, including those that form biofilms. This makes it a valuable addition to the treatment of various infections and contributes to the development of new antimicrobial strategies.

History

An obscure antiseptic called miramistin, developed by the Soviet space program in the 1950s, may prove to have modern applications in the fight against harmful viruses and bacteria. It is available for clinical use in several prior Soviet bloc countries, but barely known outside of these countries and there is almost no mention of miramistin in the English literature.

InChI:InChI=1/C26H46N2O/c1-4-5-6-7-8-9-10-11-12-13-17-21-26(29)27-22-18-23-28(2,3)24-25-19-15-14-16-20-25/h14-16,19-20H,4-13,17-18,21-24H2,1-3H3/p+1

Upstream product

• 45267-19-4 myristamidopropyl dimethylamine 
• 100-44-7 benzyl chloride 
• 544-63-8 n-tetradecanoic acid 
• 109-55-7 1-amino-3-(dimethylamino)propane 
• 39669-97-1 N-hexadecanoyl-N',N'-dimethyl-1,3-diaminopropane 
• 104-82-5 4-Methylbenzyl chloride 

Relevant academic research and scientific papers

N-(3-(Dimethyl benzyl ammonio)propyl)alkanamide chloride derivatives as corrosion inhibitors for mild steel in 1 M HCl solution: Experimental and theoretical investigation

The effects of N-(3-(dimethyl benzyl ammonio)propyl)lauramide chloride (DMBL), N-(3-(dimethyl benzyl ammonio)propyl)myristamide chloride (DMBM) and N-(3-(dimethyl benzyl ammonio)propyl)palmitamide chloride (DMBP) on the corrosion of mild carbon steel in acidic medium (1.0 M HCl) were investigated using weight loss and electrochemical measurements. The inhibition efficiency was found to be hydrophobicity- and temperature-dependent. Increasing the hydrophobic chain length increased the efficiency due to greater adsorption on the metal surface. The inhibition efficiency is directly proportional to the tested temperature. The electrochemical polarization study revealed that the tested cationic surfactants are mixed-type inhibitors. The Villamil adsorption isotherm is the better-fitted model for describing the adsorption process on the selected steel in 1.0 M HCl medium. The change in the free energy of adsorption of the synthesized cationic surfactants on the metal surface indicates that the adsorption process is chemisorption. Double-layer capacitance values obtained from electrochemical impedance spectroscopy decrease in the presence of the synthesized surfactant. Quantum chemical calculations support the experimental data and the adsorption on the metal surface.

Surface Parameters and Biological Activity of N-(3-(Dimethyl Benzyl Ammonio) Propyl) Alkanamide Chloride Cationic Surfactants

Three cationic surfactants containing amide groups were prepared by quaternization of dimethylaminopropylamine with benzyl chloride. FTIR and 1H-NMR spectroscopy were used to confirm the chemical structure of the prepared cationic surfactants. The surface parameters were estimated using surface tension measurements at three different temperatures. The prepared cationic surfactant showed a lower CMC than conventional cationic surfactants. Thermodynamic parameters of adsorption and micellization depend mainly of alkyl chain length and temperature. The adsorption process is more favorable than micellization. The biological activity of the three surfactants was estimated using inhibition zone showing that amidoamine cationic surfactants have good activity and the surfactants C12Bn is the most effective one.

ANTIVIRAL TREATMENT

The present description relates to the use of myramistin, its derivatives and the forms thereof for treating or ameliorating infections caused by enveloped viruses, methods for preparing the compounds and pharmaceutical compositions containing such compounds. In particular the use of myramistin, its derivatives and forms for treating or ameliorating infections caused by coronaviruses. More particularly, the present description relates to the use of myramistin, its derivatives and forms thereof for treating or ameliorating Coronavirus disease 2019 (COVID-19).