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1263417-22-6

4-[(1S)-(2-benzyloxy-1-{triisopropylsilyloxymethyl}ethyl)oxy]-4'-trifluoromethoxy-1,1'-biphenyl is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 4-[(1S)-(2-benzyloxy-1-{triisopropylsilyloxymethyl}ethyl)oxy]-4'-trifluoromethoxy-1,1'-biphenyl

    Cas No: 1263417-22-6

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  • 1263417-22-6 Structure

  • Basic information

    1. Product Name: 4-[(1S)-(2-benzyloxy-1-{triisopropylsilyloxymethyl}ethyl)oxy]-4'-trifluoromethoxy-1,1'-biphenyl
    2. Synonyms: 4-[(1S)-(2-benzyloxy-1-{triisopropylsilyloxymethyl}ethyl)oxy]-4'-trifluoromethoxy-1,1'-biphenyl
    3. CAS NO:1263417-22-6
    4. Molecular Formula:
    5. Molecular Weight: 574.756
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1263417-22-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-[(1S)-(2-benzyloxy-1-{triisopropylsilyloxymethyl}ethyl)oxy]-4'-trifluoromethoxy-1,1'-biphenyl(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-[(1S)-(2-benzyloxy-1-{triisopropylsilyloxymethyl}ethyl)oxy]-4'-trifluoromethoxy-1,1'-biphenyl(1263417-22-6)
    11. EPA Substance Registry System: 4-[(1S)-(2-benzyloxy-1-{triisopropylsilyloxymethyl}ethyl)oxy]-4'-trifluoromethoxy-1,1'-biphenyl(1263417-22-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1263417-22-6(Hazardous Substances Data)

1263417-22-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1263417-22-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,3,4,1 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1263417-22:
(9*1)+(8*2)+(7*6)+(6*3)+(5*4)+(4*1)+(3*7)+(2*2)+(1*2)=136
136 % 10 = 6
So 1263417-22-6 is a valid CAS Registry Number.

1263417-22-6Relevant articles and documents

NITROIMIDAZOOXAZINES AND THEIR USES IN ANTI-TUBERCULAR THERAPY

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Page/Page column 15, (2012/02/06)

The present invention relates to novel nitroimidazooxazines, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.

NITROIMIDAZOOXAZINES AND THEIR USES IN ANTI-TUBERCULAR THERAPY

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Page/Page column 38; 39, (2011/02/24)

The present invention relates to novel nitroimidazooxazines, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.

Synthesis and structure-activity relationships of varied ether linker analogues of the antitubercular drug (6 S)-2-nitro-6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro-5 H -imidazo[2,1- b ][1,3]oxazine (PA-824)

Thompson, Andrew M.,Sutherland, Hamish S.,Palmer, Brian D.,Kmentova, Iveta,Blaser, Adrian,Franzblau, Scott G.,Wan, Baojie,Wang, Yuehong,Ma, Zhenkun,Denny, William A.

supporting information; experimental part, p. 6563 - 6585 (2011/12/02)

New analogues of antitubercular drug PA-824 were synthesized, featuring alternative side chain ether linkers of varying size and flexibility, seeking drug candidates with enhanced metabolic stability and high efficacy. Both α-methyl substitution and removal of the benzylic methylene were broadly tolerated in vitro, with a biaryl example of the latter class exhibiting an 8-fold better efficacy than the parent drug in a mouse model of acute Mycobacterium tuberculosis infection and negligible fragmentation to an alcohol metabolite in liver microsomes. Extended linkers (notably propenyloxy, propynyloxy, and pentynyloxy) provided greater potencies against replicating M. tb (monoaryl analogues), with propynyl ethers being most effective under anaerobic (nonreplicating) conditions (mono/biaryl analogues). For benzyloxybenzyl and biaryl derivatives, aerobic activity was maximal with the original (OCH2) linker. One propynyloxy-linked compound displayed an 89-fold higher efficacy than the parent drug in the acute model, and it was slightly superior to antitubercular drug OPC-67683 in a chronic infection model.

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