173025-79-1

Basic information

• Product Name: 4-(4-TrifluoroMethoxyphenyl)phenol
• Synonyms: 4-(4-TrifluoroMethoxyphenyl)phenol;4'-(Trifluoromethoxy)-[1,1'-biphenyl]-4-ol
• CAS NO: 173025-79-1
• Molecular Formula: C₁₃H₉F₃O₂
• Molecular Weight: 254.2045696
• Mol File: 173025-79-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-TrifluoroMethoxyphenyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-TrifluoroMethoxyphenyl)phenol(173025-79-1)
• EPA Substance Registry System: 4-(4-TrifluoroMethoxyphenyl)phenol(173025-79-1)

Safety Data

• Hazardous Substances Data: 173025-79-1(Hazardous Substances Data)

Upstream product

• 5720-07-0 4-methoxyphenylboronic acid 
• 106-41-2 4-bromo-phenol 
• 139301-27-2 4-trifluoromethoxyphenylboronic acid 
• 777063-53-3 4-methoxy-4′-(trifluoromethoxy)-1,1′-biphenyl 
• 407-14-7 1-bromo-4-(trifluoromethoxy)benzene 

Downstream Products

• 1263417-22-6 4-[(1S)-(2-benzyloxy-1-{triisopropylsilyloxymethyl}ethyl)oxy]-4'-trifluoromethoxy-1,1'-biphenyl 
• 173025-60-0 4-[3-(4-trifluoromethoxybiphenyl-4'-oxy)propoxy]-1,3-diaminobenzene 
• 364731-97-5 C₃₁H₃₈F₃N₃O₉ 
• 220616-06-8 C₃₃H₃₈F₃NO₈ 
• 220616-11-5 3-((2S)-2-(N-hydroxyamino)-3-((4'-(trifluoromethoxy)(1,1'-biphenyl)-4-yl)oxy)propyl)-5,5-dimethyl-2,4-imidazolidinedione 
• 220616-04-6 (R)-1-Benzyloxy-3-(4'-trifluoromethoxy-biphenyl-4-yloxy)-propan-2-ol 

Relevant articles and documents

Exploiting Coupling of Boronic Acids with Triols for a pH-Dependent click-Declick Chemistry

Click-like condensation of boronic acids with specifically designed triols (boronate-triol coupling) produces stable diamantane adducts in aqueous medium, which can be controllably cleaved to initial components under acidic conditions or by using boric acid as a chemical trigger. This novel click-declick strategy allows for the creation of temporary covalent connections between two or more modular units, which was demonstrated by the synthesis of new fluorophore-labeled natural molecules (peptides, steroids), supramolecular assemblies, modified polymers, boronic acid scavengers, solid-supported organocatalysts, biodegradable COF-like materials, and dynamic combinatorial libraries.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

ERbeta ligands. Part 1: the discovery of ERbeta selective ligands which embrace the 4-hydroxy-biphenyl template.

The synthesis and structure-activity relationships of a series of simple biphenyls is described. Optimization of the 4-hydroxy-biphenyl template led to compounds with ERbeta selectivity on the order of 20-70-fold.