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126347-74-8

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126347-74-8 Usage

Chemical Properties

Pale Yellow Solid

Uses

A metabolite of Vinorelbine (V315000).

Check Digit Verification of cas no

The CAS Registry Mumber 126347-74-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,3,4 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 126347-74:
(8*1)+(7*2)+(6*6)+(5*3)+(4*4)+(3*7)+(2*7)+(1*4)=128
128 % 10 = 8
So 126347-74-8 is a valid CAS Registry Number.
InChI:InChI=1/C43H52N4O7/c1-7-25-18-26-21-42(38(49)53-5,34-28(24-46(22-25)23-26)27-12-9-10-13-31(27)44-34)30-19-29-32(20-33(30)52-4)45(3)36-41(29)15-17-47-16-11-14-40(8-2,35(41)47)37(48)43(36,51)39(50)54-6/h9-14,18-20,26,35-37,44,48,51H,7-8,15-17,21-24H2,1-6H3/t26-,35-,36+,37+,40+,41?,42-,43-/m0/s1

126347-74-8 Well-known Company Product Price

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  • USP

  • (1714528)  Vinorelbine Related Compound A  United States Pharmacopeia (USP) Reference Standard

  • 126347-74-8

  • 1714528-25MG

  • 22,487.40CNY

  • Detail

126347-74-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-deacetyl-8'-noranhydrovinblastine

1.2 Other means of identification

Product number -
Other names 17-O-deacetylvinorelbine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:126347-74-8 SDS

126347-74-8Upstream product

126347-74-8Downstream Products

126347-74-8Relevant articles and documents

Inhibitors of tubulin polymerization: Synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III

Passarella, Daniele,Giardini, Alessandra,Peretto, Bruno,Fontana, Gabriele,Sacchetti, Alessandro,Silvani, Alessandra,Ronchi, Cristina,Cappelletti, Graziella,Cartelli, Daniele,Borlak, Jurgen,Danieli, Bruno

, p. 6269 - 6285 (2008/12/21)

A series of novel hybrid compounds obtained by the attachment of anhydrovinblastine, vinorelbine, and vindoline to thiocolchicine, podophyllotoxin, and baccatin III are described. Two types of diacyl spacers are introduced. The influence of the hybrid compounds on tubulin polymerization is reported. The results highlight the importance of the length of the spacer. Immunofluorescence microscopy and flow cytometry measurements that compound with the best in vitro activity could disrupt microtubule networks in cell and prevent the formation of the proper spindle apparatus, thereby causing cell cycle arrest in the G2/M phase. The newly synthesized compounds were tested in the human lung cancer cell line A549.

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