1263482-33-2Relevant academic research and scientific papers
Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by actinosynnema pretiosum as biocatalyst
Harmrolfs, Kirsten,Bruenjes, Marco,Draeger, Gerald,Floss, Heinz G.,Sasse, Florenz,Taft, Florian,Kirschning, Andreas
, p. 2517 - 2520 (2010)
Ring closure is possible with seco-proansamitocin and two activated SNAC esters, which can be processed to ansamitocin P3 and 19-deschloro-20-demethoxy AP-3, respectively, by an AHBA-blocked mutant of Actinosynnema pretiosum. This work sheds light on the
Inhibition of Macrophage Migration Inhibitory Factor by a Chimera of Two Allosteric Binders
Cirillo, Pier F.,Asojo, Oluwatoyin A.,Khire, Uday,Lee, Yashang,Mootien, Sara,Hegan, Peter,Sutherland, Alan G.,Peterson-Roth, Elizabeth,Ledizet, Michel,Koski, Raymond A.,Anthony, Karen G.
, p. 1843 - 1847 (2019/12/02)
Human Macrophage Migration Inhibitory Factor (MIF) is a trimeric cytokine implicated in a number of inflammatory and autoimmune diseases and cancer. We previously reported that the dye p425 (Chicago Sky Blue), which bound MIF at the interface of two MIF t
