126349-24-4

Basic information

• Product Name: N2-[2(S)-Benzyl-3-sulfanylpropionyl]-L-glutamic acid 1-phenylamide
• Synonyms: ONO-BB-039-02; 4(S)-[3-Phenyl-2(S)-(sulfanylmethyl)propionamido]-5-oxo-5-(phenylamino)pentanoic acid
• CAS NO: 126349-24-4
• Molecular Formula: C₂₁H₂₄N₂O₄S
• Molecular Weight: 400.50043
• Mol File: 126349-24-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N2-[2(S)-Benzyl-3-sulfanylpropionyl]-L-glutamic acid 1-phenylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N2-[2(S)-Benzyl-3-sulfanylpropionyl]-L-glutamic acid 1-phenylamide(126349-24-4)
• EPA Substance Registry System: N2-[2(S)-Benzyl-3-sulfanylpropionyl]-L-glutamic acid 1-phenylamide(126349-24-4)

Safety Data

• Hazardous Substances Data: 126349-24-4(Hazardous Substances Data)

Upstream product

• 83024-49-1 (2S)-3-phenylcarbonylthio-2-phenylmethylpropionic acid 

Downstream Products

• 207502-36-1 C₃₇H₄₂N₂O₄SSi 

Relevant articles and documents

New orally active enkephalinase inhibitors: Their synthesis, biological activity, and analgesic properties

A series of (4s)-4-[(2S)-benzyl-3-mercaptopropionylamino]-4-(N- phenylcarbamoyl)-butyric acids has been identified as potent systemically active enkephalinase inhibitors. Structure-activity relationships (SAR) are discussed. Further chemical modification of the inhibitors was carried out in order to identify the inhibitors which are orally active in an animal model. Compounds of particular interest are the prodrug-like analogues, including 5b (ONO-9902). Their analgesic effects after oral administration were evaluated.