207502-36-1

Basic information

• Product Name: C₃₇H₄₂N₂O₄SSi
• CAS NO: 207502-36-1
• Molecular Weight: 638.903
• Mol File: 207502-36-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₇H₄₂N₂O₄SSi(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₇H₄₂N₂O₄SSi(207502-36-1)
• EPA Substance Registry System: C₃₇H₄₂N₂O₄SSi(207502-36-1)

Safety Data

• Hazardous Substances Data: 207502-36-1(Hazardous Substances Data)

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 126349-24-4 (4S)-4-(2(S)-benzyl-3-mercaptopropionylamino)-4-(N-phenylcarbamoyl)-butyric acid 
• 83024-49-1 (2S)-3-phenylcarbonylthio-2-phenylmethylpropionic acid 

Relevant articles and documents

New orally active enkephalinase inhibitors: Their synthesis, biological activity, and analgesic properties

A series of (4s)-4-[(2S)-benzyl-3-mercaptopropionylamino]-4-(N- phenylcarbamoyl)-butyric acids has been identified as potent systemically active enkephalinase inhibitors. Structure-activity relationships (SAR) are discussed. Further chemical modification of the inhibitors was carried out in order to identify the inhibitors which are orally active in an animal model. Compounds of particular interest are the prodrug-like analogues, including 5b (ONO-9902). Their analgesic effects after oral administration were evaluated.