1263575-84-3Relevant academic research and scientific papers
Organocatalytic Amination of Pyrazolones with Azodicarboxylates: Scope and Limitations
Formánek, Bed?ich,?eferna, Vít,Meazza, Marta,Rios, Ramon,Patil, Mahendra,Vesely, Jan
supporting information, p. 2362 - 2366 (2021/03/16)
The organocatalytic amination of pyrazol-5-ones with azodicarboxylates (catalyzed by quinine) is reported. This asymmetric process furnishes enantiomerically enriched hydrazine adducts containing quaternary stereocenters in high yields (74–96 %) and enant
Tunable Aerobic Oxidative Hydroxylation/Dehydrogenative Homocoupling of Pyrazol-5-ones under Transition-Metal-Free Conditions
Sheng, Xuguang,Zhang, Jinlong,Yang, Huameng,Jiang, Gaoxi
supporting information, p. 2618 - 2621 (2017/05/24)
A practical and tunable transition-metal-free aerobic oxidation of pyrazol-5-ones preparing either 4-hydroxypyrazoles (via C-H hydroxylation) or bispyrazoles (via dehydrogenative homocoupling) is described. The K2CO3/dioxane reagent system predominately promoted hydroxylation to deliver the α-hydroxylated pyrazoles. In contrast, the formation of bispyrazoles was overwhelmingly preferred with CH3CN as the reaction medium without any additives.
