1263786-32-8

Upstream product

• 5344-90-1 2-Aminobenzyl alcohol 
• 108-59-8 malonic acid dimethyl ester 
• 16695-14-0 Malonic acid monomethyl ester 

Downstream Products

• 1263786-38-4 methyl (2R,3S,4aR)-3-(4-chlorophenyl)-4a-methyl-1-oxo-1,2,3,4,4a,6-hexahydrobenzo[d]pyrido[2,1-b][1,3]oxazine-2-carboxylate 
• 1263786-53-3 methyl (2R,3S,4aR)-4a-methyl-3-(3-nitrophenyl)-1-oxo-1,2,3,4,4a,6-hexahydrobenzo[d]pyrido[2,1-b][1,3]oxazine-2-carboxylate 
• 1263786-54-4 methyl (2R,3S,4aR)-4a-methyl-3-(4-nitrophenyl)-1-oxo-1,2,3,4,4a,6-hexahydrobenzo[d]pyrido[2,1-b][1,3]oxazine-2-carboxylate 
• 1263786-43-1 methyl (2R,3S,4aR)-3-(4-methoxyphenyl)-4a-methyl-1-oxo-1,2,3,4,4a,6-hexahydrobenzo[d]pyrido[2,1-b][1,3]oxazine-2-carboxylate 
• 1263786-45-3 methyl (2R,3S,4aR)-3-(3-methylphenyl)-4a-methyl-1-oxo-1,2,3,4,4a,6-hexahydrobenzo[d]pyrido[2,1-b][1,3]oxazine-2-carboxylate 
• 1263786-35-1 methyl (2R,3S,4aR)-3-(4-fluorophenyl)-4a-methyl-1-oxo-1,2,3,4,4a,6-hexahydrobenzo[d]pyrido[2,1-b][1,3]oxazine-2-carboxylate 
• 1263786-46-4 methyl (2R,3S,4aR)-3-(4-methylphenyl)-4a-methyl-1-oxo-1,2,3,4,4a,6-hexahydrobenzo[d]pyrido[2,1-b][1,3]oxazine-2-carboxylate 
• 1263786-37-3 methyl (2R,3S,4aR)-3-(3-chlorophenyl)-4a-methyl-1-oxo-1,2,3,4,4a,6-hexahydrobenzo[d]pyrido[2,1-b][1,3]oxazine-2-carboxylate 
• 1263786-39-5 methyl (2R,3S,4aR)-3-(3-bromophenyl)-4a-methyl-1-oxo-1,2,3,4,4a,6-hexahydrobenzo[d]pyrido[2,1-b][1,3]oxazine-2-carboxylate 
• 1263786-42-0 methyl (2R,3S,4aR)-3-(3-methoxyphenyl)-4a-methyl-1-oxo-1,2,3,4,4a,6-hexahydrobenzo[d]pyrido[2,1-b][1,3]oxazine-2-carboxylate 
• 1263786-36-2 methyl (2R,3S,4aR)-3-(2-chlorophenyl)-4a-methyl-1-oxo-1,2,3,4,4a,6-hexahydrobenzo[d]pyrido[2,1-b][1,3]oxazine-2-carboxylate 

Relevant academic research and scientific papers

A one-pot asymmetric organocatalytic tandem reaction for the synthesis of oxazine derivatives

An easy one-pot tandem reaction catalyzed by a chiral secondary amine for the synthesis of optically active oxazine derivatives has been performed and the corresponding substituted benzo[d]pyrido[2,1-b][1,3]oxazine derivatives were afforded in generally high yields (up to 99%) and excellent enantioselectivities (up to >99%).

Diastereo-and enantioselective synthesis of oxazine and oxazolidine derivatives with a chiral quaternary carbon center under multifunctional catalysis

An easy one-pot, multistep cascade reaction which could afford a series of substituted benzo[d]pyrido[2,1-b]oxazolidine and [1,3]oxazine derivatives in a highly enantio-(up to 98% ee) and diastereoselective (4:1 to >20:1 dr) manner with generally good to excellent yields (up to 99%) has been developed. This well designed strategy could be applied to a wide scope of substrates under mild conditions with simple operations.