1263808-46-3

Upstream product

• 151838-62-9 N-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 67123-97-1 (R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 1263808-84-9 tert-butyl-3-(1-benzylpiperidin-4-ylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylate 
• 54582-33-1 1,1'-carbonyldiimidazole 

Downstream Products

• 1263808-47-4 2-[1-(4-methylbenzyl)piperidin-4-yl]-10,10a-dihydro-5H-imidazo[1,5-b]isoquinoline-1,3-dione 
• 1263808-49-6 2-[1-(4-tert-butylbenzyl)piperidin-4-yl]-10,10a-dihydro-5H-imidazo[1,5-b]isoquinoline-1,3-dione 
• 1263808-51-0 2-[1-(4-methoxybenzyl)piperidin-4-yl]-10,10a-dihydro-5H-imidazo[1,5-b]isoquinoline-1,3-dione 
• 1263808-53-2 2-[1-(4-nitrobenzyl)piperidin-4-yl]-10,10a-dihydro-5H-imidazo[1,5-b]isoquinoline-1,3-dione 
• 1263808-55-4 2-[1-(4-fluorobenzyl)piperidin-4-yl]-10,10a-dihydro-5H-imidazo[1,5-b]isoquinoline-1,3-dione 
• 1263808-57-6 2-[1-(cyclohexylmethyl)piperidin-4-yl]-10,10a-dihydro-5H-imidazo[1,5-b]isoquinoline-1,3-dione 

Relevant academic research and scientific papers

New synthesis of tic-hydantoins sigma-1 ligands and pharmacological evaluation on cocaine-induced stimulant effects

Activation of the newly identified σ1 chaperone protein is involved in several aspects of the psychostimulant and addictive effects of cocaine. The development of ligands that selectively target the σ1 protein may lead to putative potent anti-cocaine agen