126396-89-2Relevant academic research and scientific papers
POTENTIAL ANTIDEPRESSANTS: 10-AMINO-2-CHLORO-10,11-DIHYDRODIBENZOTHIEPINS
Valenta, Vladimir,Vlkova, Marie,Holubek, Jiri,Metysova, Jirina,Protiva, Miroslav
, p. 1979 - 1994 (2007/10/02)
Reduction of N-(2-chloro-10,11-dihydrodibenzothiepin-10-yl)formamide with lithium aluminium hydride resulted in the methylamino compound IV.The dimethylamino compound V was obtained by methylation of 10-amino-2-chloro-10,11-dihydrodibenzothiepin with formic acid and aqueous formaldehyde.Substitution reactions of 2,10-dichloro-10,11-dihydrodibenzothiepin with a series of primary and secondary amines afforded the title compounds VI to XXVIII.The bases were transformed to salts and pharmacologically tested.Only the pyrrolidino compound IX (hydrogen succinate VUFB-15551) showed a clear pharmacological profile of a potential antidepressant.
