126399-06-2Relevant academic research and scientific papers
Phosphatase Binding Compounds and Methods of Using Same
-
Page/Page column 3; 232, (2020/07/25)
The present invention provides bifunctional compounds that efficiently dephosphorylate certain phospho-activated target proteins. Such target proteins can be any protein involved in the pathway of a disease or disorder, such as but not limited to cancer, neurodegeneration, metabolic disease, diabetes, insulin resistance, and so forth.
Total synthesis of motuporin (nodularin-v)
Bauer, Shawn M.,Armstrong, Robert W.
, p. 6355 - 6366 (2007/10/03)
The serine/threonine phosphatase (protein phosphatase 1 and 2A) inhibitors constitute a biologically and structurally interesting class of natural products. Among this class of inhibitors are cyclic pentapeptides (nodularins) and cyclic heptapeptides (mic
An asymmetric synthesis of ADDA, and ADDA-glycine dipeptide using the ss-lactam synthon method
Cundy, Darren J.,Donohue, Andrew C.,McCarthy, Tom D.
, p. 559 - 567 (2007/10/03)
The paper describes the synthesis of the W-Boc lactam 4, and demonstrates that it is an important intermediate in the synthesis of dipeptide 5 (X = H, n = 0, R = Me), an analogue of the ADDA-GIu dipeptide 3. In addition we have described a mild method for the preparation of the amino acid salt ADDA-HC1, and provided synthetic methods, and full characterisation for the previously 'elusive' free amino acid ADDA.
Towards an asymmetric synthesis of ADDA conjugates
Cundy, Darren J.,Donohue, Andrew C.,McCarthy, Tom D.
, p. 5125 - 5128 (2007/10/03)
In order to develop a general synthesis of ADDA containing peptides, an asymmetric synthesis of the β-lactum 4 and initial investigations into its opening with aminoesters is described.
Stereocontrolled Synthesis of (2S,3S,8S,9S,4E,6E)-3-Amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic Acid (Adda), the Amino Acid Characteristic of Microcystins and Nodularin
Beatty, Mark F.,Jennings-White, Clive,Avery, Mitchell A.
, p. 1637 - 1642 (2007/10/02)
(4R,5S)-4-Methyl-5-phenyloxazolidin-2-one has been used as a chiral template to construct the 8S and 9S chiral centres of (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid (Adda), the 2S and 3S centres being derived from D-asp
TOTAL SYNTHESIS OF ADDA, THE UNIQUE C20 AMINO ACID OF CYANOBACTERIAL HEPATOTOXINS
Namikoshi, Michio,Rinehart, Kenneth L.,Dahlem, Andrew M.,Beasley, Val R.,Carmichael, Wayne W.
, p. 4349 - 4352 (2007/10/02)
Synthetic (2S,3R)-3-Amino-4-hydroxy-2-methylbutanoic acid, γ-lactone, and (4S,5S)-2,4-dimethyl-5-methoxy-6-phenyl-2-hexen-1-ol were oxidized and linked to give (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoic acid (Adda).
