126399-11-9

Upstream product

• 126399-05-1 (2E,4S,5S)-5-methoxy-2,4-dimethyl-6-phenylhex-2-en-1-ol 
• 126399-03-9 cis/trans-(4S,5S)-ethyl-5-methoxy-2,4-dimethyl-6-phenylhex-2-enoate 
• 126399-05-1 cis/trans-(4S,5S)-5-methoxy-2,4-dimethyl-6-phenylhex-2-en-1-ol 
• 126399-03-9 (E)-(S)-5-Methoxy-2,4-dimethyl-6-phenyl-hex-2-enoic acid ethyl ester 
• 126399-04-0 (2E,4S,5S)-ethyl 5-methoxy-2,4-dimethyl-6-phenylhex-2-enoate 

Downstream Products

• 211816-18-1 (2E,4S,5S)-1-diphenylphosphinoyl-5-methoxy-2,4-dimethyl-6-phenylhex-2-ene 
• 134526-68-4 (2S,3S,8S,9S,4E,6E)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldecadienoic acid trifluoroacetate 
• 126399-06-2 (2E,4S,5S)-5-methoxy-2,4-dimethyl-6-phenylhex-2-enyl(triphenyl)phosphonium bromide 
• 134440-91-8 (2S,3S,8S,9S,4E,6Z)-3-(tert-butoxycarbonyl)amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoic acid methyl ester 
• 134440-91-8 (4Z,6E)-(2S,3S,8S,9S)-3-tert-Butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid methyl ester 
• 134440-91-8 (4Z,6Z)-(2S,3S,8S,9S)-3-tert-Butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid methyl ester 
• 134440-91-8 (2S,3S,8S,9S,4E,6E)-3-(tert-butoxycarbonyl)amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoic acid methyl ester 
• 134440-92-9 (2S,3S,4E,6E,8S,9S)-3-(tert-butoxycarbonyl)amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoic acid 
• 126399-06-2 ((E)-(4S,5S)-5-Methoxy-2,4-dimethyl-6-phenyl-hex-2-enyl)-triphenyl-phosphonium; bromide 
• 129394-57-6 2-{(2E,4E)-(1S,6S,7S)-1-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-7-methoxy-4,6-dimethyl-8-phenyl-octa-2,4-dienyl}-isoindole-1,3-dione 
• 129394-57-6 2-{(2E,4E)-(1S,6S,7S)-1-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-7-methoxy-4,6-dimethyl-8-phenyl-octa-2,4-dienyl}-isoindole-1,3-dione 
• 129371-97-7 (4E,6E)-(2S,3S,8S,9S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid methyl ester 
• 126399-08-4 (4E,6E)-(2S,3S,8S,9S)-3-Benzyloxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid ethyl ester 
• 126456-06-2 (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid 

Relevant academic research and scientific papers

Total synthesis of motuporin (nodularin-v)

The serine/threonine phosphatase (protein phosphatase 1 and 2A) inhibitors constitute a biologically and structurally interesting class of natural products. Among this class of inhibitors are cyclic pentapeptides (nodularins) and cyclic heptapeptides (mic

Towards an asymmetric synthesis of ADDA conjugates

In order to develop a general synthesis of ADDA containing peptides, an asymmetric synthesis of the β-lactum 4 and initial investigations into its opening with aminoesters is described.

Stereocontrolled Synthesis of (2S,3S,8S,9S,4E,6E)-3-Amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic Acid (Adda), the Amino Acid Characteristic of Microcystins and Nodularin

(4R,5S)-4-Methyl-5-phenyloxazolidin-2-one has been used as a chiral template to construct the 8S and 9S chiral centres of (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid (Adda), the 2S and 3S centres being derived from D-asp

Total synthesis of N-phthaloyl adda methyl ester: All stereocenters originating from a single chiral epoxyalcohol

Selective ring opening of (2S,3R)-epoxide of 4-benzyloxy-cis-2-buten-1-ol either at 2- or 3-position ensures stereospecific construction of all the chiral centers of Adda.

TOTAL SYNTHESIS OF ADDA, THE UNIQUE C20 AMINO ACID OF CYANOBACTERIAL HEPATOTOXINS

Synthetic (2S,3R)-3-Amino-4-hydroxy-2-methylbutanoic acid, γ-lactone, and (4S,5S)-2,4-dimethyl-5-methoxy-6-phenyl-2-hexen-1-ol were oxidized and linked to give (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoic acid (Adda).