126402-83-3Relevant academic research and scientific papers
Ti(IV) MEDIATED TRANSESTERIFICATION AND REGIO- AND STEREO-SPECIFIC CYCLOADDITION OF IMINES OF α-AMINO ESTERS. REVERSAL OF NORMAL REGIOCHEMISTRY.
Barr, Darrin A.,Grigg, Ronald,Sridharan, Visuvanathar
, p. 4727 - 4730 (1989)
Ti(i-PrO)3Cl or Ti(i-PrO)2Cl2 in combination with triethylamine effect regio- and stereo-specific cycloaddition of imines of α-amino methyl esters to methyl acrylate at room temperature with reversal of the normal regiochemistry.Transesterification of the imine ester group competes with cycloaddition leading to a mixture of pyrrolidines bearing C(2) methyl and isopropyl ester substituens.
