1264148-75-5

Upstream product

• 139712-95-1 C₁₈H₂₀N₂O₃S 
• 152873-15-9 (S)-3-((1-tosylaziridin-2-yl)methyl)-1H-indole 
• 7524-52-9 (S)-tryptophan methyl ester hydrochloride 
• 79659-73-7 N-<(4-Methylphenyl)sulfonyl>tryptophan Methyl Ester 

Downstream Products

• 1264149-17-8 N-((S)-1-(N-((S)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)methylsulfonamido)-3-(1H-indol-3-yl)propan-2-yl)-4-methylbenzenesulfonamide 
• 1264149-36-1 3,3'-((2S,5S)-1-(methylsulfonyl)-4-tosylpiperazine-2,5-diyl)bis(methylene)bis(1H-indole) 
• 1264148-96-0 (S)-methyl 2-(N-((S)-3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)propyl)methylsulfonamido)-3-(1H-indol-3-yl)propanoate 

Relevant academic research and scientific papers

Regioselective ring-opening of amino acid-derived chiral aziridines: An easy access to cis-2,5-disubstituted chiral piperazines

An efficient four-step synthetic strategy for cis-2,5-disubstituted chiral piperazines derived from amino-acid-based aziridines is described. The key steps in this strategy are the highly regioselective boron trifluoride diethyl etherate (BF3·OEt2)-mediated ring-opening of less-reactive N-Ts chiral aziridines by α-amino acid methyl ester hydrochloride followed by Mitsunobu cyclization. This protocol has been used in an attempt to construct the piperazine core framework of natural product (+)-piperazinomycin. The pied piperazines: A four-step efficient synthetic strategy for cis-2,5-disubstituted chiral piperazines derived from amino acid-based aziridines is described. The key reaction steps are the highly regioselective BF3·OEt2 mediated ring-opening of less-reactive N-Ts chiral aziridines by α-amino acid methyl ester hydrochlorides, followed by a Mitsunobu cyclization. This protocol has been used in an attempt to construct the piperazine core framework of natural product (+)-piperazinomycin. Copyright