126443-18-3

Basic information

• Product Name: 2-Propen-1-one, 3-(4-bromophenyl)-1-(4-methoxyphenyl)-, (2E)-
• CAS NO: 126443-18-3
• Molecular Formula: C16H13BrO2
• Molecular Weight: 317.182
• Mol File: 126443-18-3.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 3-(4-bromophenyl)-1-(4-methoxyphenyl)-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 3-(4-bromophenyl)-1-(4-methoxyphenyl)-, (2E)-(126443-18-3)
• EPA Substance Registry System: 2-Propen-1-one, 3-(4-bromophenyl)-1-(4-methoxyphenyl)-, (2E)-(126443-18-3)

Safety Data

• Hazardous Substances Data: 126443-18-3(Hazardous Substances Data)

Upstream product

• 20912-79-2 4-methoxyphenacylidene dimethylsulphurane 
• 19350-68-6 p-bromobenzaldehyde tosylhydrazone 
• 27465-66-3 4-bromocinnamoyl chloride 
• 33397-21-6 tris(4-methoxyphenyl)bismuth 
• 1122-91-4 4-bromo-benzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 106-37-6 1.4-dibromobenzene 
• 7448-86-4 1-(4-methoxyphenyl)prop-2-en-1-one 

Downstream Products

• 160210-32-2 (2E)-3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one 
• 1336984-96-3 (E)-ethyl 2-(4-(4-bromophenyl)-6-(4-methoxyphenyl)-3,4-dihydro-2H-pyran-2-ylidene)acetate 
• 1336984-97-4 (E)-ethyl 2-(4-(4-bromophenyl)-6-(4-methoxyphenyl)-3,4-dihydro-2H-pyran-2-ylidene)acetate 
• 1021493-95-7 3-(4-bromophenyl)-1-(4-methoxyphenyl)-4-nitrobutan-1-one 

Relevant articles and documents

Novel solid-supported dimerization-heteroannulation of chalcones: simple and efficient synthesis of 2,4,6-triaryl-3-methylarylpyridines

2,4,6-Triaryl-3-methylarylpyridines were obtained, in 60-70% yield, by a novel one-pot solventless solid-supported dimerization-heteroannulation reaction of chalcones and compounds possessing terminal -CONH2 functionality, at 125-135 °C, using immobilized Bi(III) nitrate and Zn(II) chloride as co-catalyst. Initially, chalcones were prepared, in nearly quantitative yield, by a modified aldol condensation, in neutral aqueous medium, in the presence of p-toluenesodium sulfonate.

Monoamine oxidase inhibitory activity of methoxy-substituted chalcones

The MAO-B inhibitory activity of chalcone (1, 3- diphenyl-2-propen-1-one) based compounds arise from its structural similarity with 1, 4-diphenyl-2-butene, a known MAO-B inhibitor. Based on our previous report, the methoxy-substituted with fluorine containing chalcones are promising reversible MAO-B inhibitors, while in the present study, a series of methoxylated chalcones (C1-C9) bearing substitution on the para position of ring B was synthesized and evaluated for their human monoamine oxidase inhibitory activity. With the exception of (2E)-1-(4-methoxyphenyl)-3-(4-nitrophenyl) prop-2-en-1-one (C7), which is a nonselective inhibitor, the chalcones exhibited competitive, selective, and reversible inhibition of hMAO-B. The most potent compound, (2E)-3-[4-(dimethylamino) phenyl]-1-(4-methoxyphenyl) prop-2-en-1-one (C5), showed the best inhibitory activity towards hMAO-B (IC50 = 0.29 ± 0.011 μM; Ki = 0.14 ± 0.001 μM). The reversibility of MAO-B inhibition by compound C5 was demonstrated by the recovery of enzyme activity after dialysis of mixtures containing enzyme and inhibitor. The reversiblity of C5 was 25.38 ± 1.40 and 92.00 ± 3.87% before and after dialysis, respectively. PAMPA was carried out to evaluate the blood-brain barrier effects of the designated compounds. Moreover, the most potent MAO-B inhibitor, C5, was found to be nontoxic towards cultured hepatic cells at 5 and 25 μM, with 97 and 90% viability. Molecular docking study was performed against hMAO-B to observe the binding site interactions of the lead compound.

Method using Ti (III) complex catalytic alkyne selective hydrogenation reduction to prepare chalcone compounds

The invention discloses a method for preparing chalcone compounds through selective hydrogenation of Ti (III) complexes to prepare chalcone compounds, wherein zinc powder is used as a catalyst, zinc powder is a reducing agent, triethylamine hydrochloride is a proton source, and an alkyne and triethylamine hydrochloride are subjected to radical selective addition reaction under the protection of inert gas to generate chalcone compounds. The reaction condition is mild, the operation is simple, the reaction time is short, the reaction product is single, the atom economy is high, and only the product needs to be separated by simple column chromatography after the reaction is finished. The chalcone compound has wide biological activity and medicinal value.

Palladium anchored on guanidine-terminated magnetic dendrimer (G3-Gu-Pd): An efficient nano-sized catalyst for phosphorous-free Mizoroki-Heck and copper-free Sonogashira couplings in water

In this research, a novel type of Fe3O4&at;silica-supported dendrimer capped by guanidine groups for immobilization of palladium was reported. This novel nano-sized catalyst was characterized by FTIR, TGA, XRD, FESEM, EDX, VSM, XPS and HRTEM methods. Enhanced catalytic activity of the prepared catalyst in Mizoroki-Heck and copper-free Sonogashira coupling reactions were evaluated in water as a green solvent. The influence of the various reaction parameters such as catalyst dosage, time and temperature on two mentioned C–C coupling reactions were studied. Results showed that the catalyst could be easily recovered by simple separation by an external magnet and reused for five cycles of recovery without considerable losing of its activity.