1264498-77-2

Upstream product

• 207740-21-4 2-(1,4-dimethoxynaphth-2-yl)ethylamine 
• 104-88-1 4-chlorobenzaldehyde 
• 1264498-72-7 N-(4-chlorobenzylidene)-2-(1,4-dimethoxynaphthalen-2-yl)ethanamine 
• 76-02-8 trifluoroacetyl chloride 

Downstream Products

• 1264498-87-4 2-(2,2,2-trichloroacetyl)-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline-5,10-dione 
• 1264498-60-3 C₁₉H₁₀ClNO₂ 

Relevant academic research and scientific papers

Synthesis of 1-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10- diones

1,2-Disubstituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones are prepared for the first time through an activated Pictet-Spengler reaction of the corresponding imines of 2-(1,4-dimethoxynaphth-2-yl)ethylamine in the presence of an acyl chloride and AlCl3 followed by an oxidation with silver(ii) oxide in nitric acid. Depending on the reaction conditions the N-trichloroacetyl protecting group could be cleaved off, converted to an N-methoxycarbonyl group or transformed to an N-(2-oxoacetamide) moiety. The synthesized 1,2-disubstituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones constitute a new class of quinones, which has not been reported yet.