2-(2,2,2-trichloroacetyl)-5,10-dimethoxy-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline

Base Information

Chemical Name:2-(2,2,2-trichloroacetyl)-5,10-dimethoxy-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline
CAS No.:1264498-77-2
Molecular Formula:C₂₃H₁₉Cl₄NO₃
Molecular Weight:499.221
Hs Code.:

Synonyms:2-(2,2,2-trichloroacetyl)-5,10-dimethoxy-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline

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Chemical Property of 2-(2,2,2-trichloroacetyl)-5,10-dimethoxy-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline

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Technology Process of 2-(2,2,2-trichloroacetyl)-5,10-dimethoxy-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline

There total 3 articles about 2-(2,2,2-trichloroacetyl)-5,10-dimethoxy-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1264498-72-7
N-(4-chlorobenzylidene)-2-(1,4-dimethoxynaphthalen-2-yl)ethanamine

: 76-02-8
trifluoroacetyl chloride

: 1264498-77-2
2-(2,2,2-trichloroacetyl)-5,10-dimethoxy-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline

Guidance literature:: N-(4-chlorobenzylidene)-2-(1,4-dimethoxynaphthalen-2-yl)ethanamine; trifluoroacetyl chloride; With potassium iodide; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h; Molecular sieve; Inert atmosphere;

With aluminum (III) chloride; In 1,2-dichloro-ethane; for 3h; Reflux; Inert atmosphere;
DOI:10.1039/c0ob00391c

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1264498-77-2
2-(2,2,2-trichloroacetyl)-5,10-dimethoxy-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium sulfate / dichloromethane / 4 h / Reflux

2.1: potassium iodide / 1,2-dichloro-ethane / 0.5 h / 20 °C / Molecular sieve; Inert atmosphere

2.2: 3 h / Reflux; Inert atmosphere

With magnesium sulfate; potassium iodide; In dichloromethane; 1,2-dichloro-ethane; 2.1: Pictet-Spengler cyclisation / 2.2: Pictet-Spengler cyclisation;
DOI:10.1039/c0ob00391c

Reference yield:

: 207740-21-4
2-(1,4-dimethoxynaphth-2-yl)ethylamine

: 1264498-77-2
2-(2,2,2-trichloroacetyl)-5,10-dimethoxy-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium sulfate / dichloromethane / 4 h / Reflux

2.1: potassium iodide / 1,2-dichloro-ethane / 0.5 h / 20 °C / Molecular sieve; Inert atmosphere

2.2: 3 h / Reflux; Inert atmosphere

With magnesium sulfate; potassium iodide; In dichloromethane; 1,2-dichloro-ethane; 2.1: Pictet-Spengler cyclisation / 2.2: Pictet-Spengler cyclisation;
DOI:10.1039/c0ob00391c