1264591-53-8

Upstream product

• 420-04-2 CYANAMID 
• 536-90-3 m-Anisidine 
• 497-19-8 sodium carbonate 

Downstream Products

• 1333391-44-8 {4-[2-(phenyl(methyl)amino)-4-methylthiazol-5-yl]pyrimidin-2-yl}-(3-methoxyphenyl)amine 
• 1333391-46-0 {4-[2-(m-tolyl(methyl)amino)-4-methylthiazol-5-yl]pyrimidin-2-yl}-(3-methoxyphenyl)amine 
• 1286280-96-3 {4-[2-(p-tolyl(methyl)amino)-4-methylthiazol-5-yl]pyrimidin-2-yl}-(3-methoxyphenyl)amine 
• 1333391-50-6 (4-{2-[(2-chlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-(3-methoxyphenyl)amine 
• 1333391-45-9 (4-{2-[(4-chlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-(3-methoxyphenyl)amine 
• 1333391-43-7 (4-{2-[(3,4-dichlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-(3-methoxyphenyl)amine 
• 1333391-41-5 (4-{2-[(3-chloro-4-fluorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-(3-methoxyphenyl)amine 

Relevant academic research and scientific papers

Synthesis of novel thiazolyl-pyrimidines and their anticancer activity in vitro

A series of novel compounds 7-43 were prepared via the condensation of enaminones 4a-h and the guanidines carbonate 6a-f. The structures of these newly synthesized compounds were confirmed by 1H-NMR, MS, EA and IR. All the compounds were tested for their cytotoxic activity in vitro against human cancer cell lines including Ishikawa, A549, BEL-7404, SPC-A-01 and SGC-7901. Most of them showed moderate cytotoxic against the tested cell lines. Among them, the most potent compounds 9 and 30 exhibited more efficient activity against Ishikawa, A549. Thiazolyl-pyrimidines were synthesized by the general pyrimidine condensation of Bredereck and their in-vitro anticancer activities were evaluated. Copyright