1286280-96-3

Upstream product

• 71047-48-8 1-(4-methyl-2-(p-tolylamino)-1,3-thiazol-5-yl)ethan-1-one 
• 1286280-97-4 3-dimethylamino-1-[4-methyl-2-(methyl(p-tolyl)amino)thiazol-5-yl]propenone 
• 1264591-53-8 CH₂O₃*C₈H₁₁N₃O 
• 536-90-3 m-Anisidine 
• 1694-29-7 3-chloropentane-2,4-dione 

Relevant academic research and scientific papers

Synthesis of novel thiazolyl-pyrimidines and their anticancer activity in vitro

A series of novel compounds 7-43 were prepared via the condensation of enaminones 4a-h and the guanidines carbonate 6a-f. The structures of these newly synthesized compounds were confirmed by 1H-NMR, MS, EA and IR. All the compounds were tested for their cytotoxic activity in vitro against human cancer cell lines including Ishikawa, A549, BEL-7404, SPC-A-01 and SGC-7901. Most of them showed moderate cytotoxic against the tested cell lines. Among them, the most potent compounds 9 and 30 exhibited more efficient activity against Ishikawa, A549. Thiazolyl-pyrimidines were synthesized by the general pyrimidine condensation of Bredereck and their in-vitro anticancer activities were evaluated. Copyright