1264669-05-7

Basic information

• Product Name: HOCH₂C₆H₂(OCH₃)(OSi(CH₃)(C(CH₃)3)CH₂Sn(CH₃)3)Sn(CH₃)3
• CAS NO: 1264669-05-7
• Molecular Weight: 594.041
• Mol File: 1264669-05-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: HOCH₂C₆H₂(OCH₃)(OSi(CH₃)(C(CH₃)3)CH₂Sn(CH₃)3)Sn(CH₃)3(CAS DataBase Reference)
• NIST Chemistry Reference: HOCH₂C₆H₂(OCH₃)(OSi(CH₃)(C(CH₃)3)CH₂Sn(CH₃)3)Sn(CH₃)3(1264669-05-7)
• EPA Substance Registry System: HOCH₂C₆H₂(OCH₃)(OSi(CH₃)(C(CH₃)3)CH₂Sn(CH₃)3)Sn(CH₃)3(1264669-05-7)

Safety Data

• Hazardous Substances Data: 1264669-05-7(Hazardous Substances Data)

Upstream product

• 1066-45-1 trimethyltin(IV)chloride 
• 113931-96-7 4-<(tert-butyldimethylsilyl)oxy>-3-methoxybenzyl alcohol 

Relevant articles and documents

Tubulin-binding dibenz[c,e]oxepines as colchinol analogues for targeting tumour vasculature

Various methoxy- and hydroxy-substituted dibenz[c,e]oxepines were prepared via the copper(i)-induced coupling of ether-tethered arylstannanes or the dehydrative cyclisation of 1,1′-biphenyl-2,2′-dimethanols, assembled using the Ullmann cross-coupling of ortho-bromoaryl carbonyl compounds. The dibenzoxepines were screened for their ability to inhibit tubulin polymerisation and the in vitro growth of K562 human chronic myelogenous leukemia cells. The most active was 5,7-dihydro-3,9,10,11-tetramethoxydibenz[c,e]oxepin-4-ol, whose tubulin inhibitory and cytotoxicity (IC50) values were 1 μM and 40 nM, respectively.