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4-[1-Benzyl-5-(2-cyclopentyl-acetylamino)-1H-indol-3-ylmethyl]-3-methoxy-benzoic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 126502-24-7 Structure
  • Basic information

    1. Product Name: 4-[1-Benzyl-5-(2-cyclopentyl-acetylamino)-1H-indol-3-ylmethyl]-3-methoxy-benzoic acid
    2. Synonyms:
    3. CAS NO:126502-24-7
    4. Molecular Formula:
    5. Molecular Weight: 496.606
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 126502-24-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-[1-Benzyl-5-(2-cyclopentyl-acetylamino)-1H-indol-3-ylmethyl]-3-methoxy-benzoic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-[1-Benzyl-5-(2-cyclopentyl-acetylamino)-1H-indol-3-ylmethyl]-3-methoxy-benzoic acid(126502-24-7)
    11. EPA Substance Registry System: 4-[1-Benzyl-5-(2-cyclopentyl-acetylamino)-1H-indol-3-ylmethyl]-3-methoxy-benzoic acid(126502-24-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 126502-24-7(Hazardous Substances Data)

126502-24-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 126502-24-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,5,0 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 126502-24:
(8*1)+(7*2)+(6*6)+(5*5)+(4*0)+(3*2)+(2*2)+(1*4)=97
97 % 10 = 7
So 126502-24-7 is a valid CAS Registry Number.

126502-24-7Downstream Products

126502-24-7Relevant articles and documents

Evolution of a series of peptidoleukotriene antagonists: Synthesis and structure/activity relationships of 1,3,5-substituted indoles and indazoles

Matassa,Maduskuie Jr.,Shapiro,Hesp,Snyder,Aharony,Krell,Keith

, p. 1781 - 1790 (1990)

1,3,5-Substituted indoles and indazoles have been studied as receptor antagonists of the peptidoleukotrienes. The best of these compounds generally had a methyl group at the N1 position, a [(cyclopentyloxy)carbonyl]amino or 2-cyclopentylacetamido or N'-cyclopentylureido group at the C-5 position, and an arysulfonyl amide group as part of the acidic chain at the C-3 position of the ring. Such compounds had in vitro dissociation constants K(B) in the range 10-9-10-11 M on guinea pig trachea against LTE4 as agonist and inhibition constants (K(i)) ≤ 10-9 M on guinea pig parenchymal membranes against [3H]LTD4. A number of compounds were orally effective at doses ≤1 mg/kg in blocking LTD4-induced 'dyspnea' in guinea pigs. Compound 45 [N-[4-[[5-[[cyclopentyloxy)carbonyl]amino]-1-methylindol-3-yl]methyl]- 3-methoxybenzoyl]-2-methyl]benzenesulfonamide, ICI 204,219; pK(B) = 9.67 ± 0.13, K(i) = 0.3 ± 0.03 nM, po ED50 = 0.3 mg/kg] is currently under clinical investigation for asthma. In the indole series, certain alkylsulfonyl amides possessing a 3-cyanobenzyl substituent at the N-1 position (60, 61) were produced that had K(B) ≤ 10-9 M on guinea pig trachea.

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