1265157-04-7

Basic information

• Product Name: 1-(3-(2-fluoroethoxy)phenyl)piperazine
• Synonyms: 1-(3-(2-fluoroethoxy)phenyl)piperazine
• CAS NO: 1265157-04-7
• Molecular Weight: 224.278
• Mol File: 1265157-04-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(3-(2-fluoroethoxy)phenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-(2-fluoroethoxy)phenyl)piperazine(1265157-04-7)
• EPA Substance Registry System: 1-(3-(2-fluoroethoxy)phenyl)piperazine(1265157-04-7)

Safety Data

• Hazardous Substances Data: 1265157-04-7(Hazardous Substances Data)

Upstream product

• 198627-86-0 1,1-dimethylethyl 4-(3-hydroxyphenyl)-1-piperazinecarboxylate 
• 1265156-90-8 tert-butyl 4-(3-(2-fluoroethoxy)phenyl)piperazine-1-carboxylate 

Relevant articles and documents

Novel indole-based sigma-2 receptor ligands: synthesis, structure-affinity relationship and antiproliferative activity

We report the synthesis and biological evaluation of a series of indole-based σ2 receptor ligands derived from siramesine. In vitro competition binding assays showed that these analogues possessed high to moderate affinity and selectivity for σ2 receptors. Structure-affinity relationship analyses of these indole-based σ2 receptor ligands were performed. In the 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, 1a and 1b displayed significant and comparable antiproliferative activity in DU145, MCF7 and C6 cells to siramesine. In cell cycle analyses, compounds 1a, 1b and siramesine were found to induce a G1 phase cell cycle arrest in DU145 cells using flow cytometry. The combination of 5,6-dimethoxyisoindoline scaffold and N-(4-fluorophenyl)indole moiety was identified as a new σ2 receptor ligand deserving further investigation as an antitumor agent.