1265205-86-4Relevant academic research and scientific papers
Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation
Spry, Christina,Sewell, Alan L.,Hering, Yuliya,Villa, Mathew V.J.,Weber, Jonas,Hobson, Stephen J.,Harnor, Suzannah J.,Gul, Sheraz,Marquez, Rodolfo,Saliba, Kevin J.
supporting information, p. 1139 - 1147 (2017/12/15)
Survival of the human malaria parasite Plasmodium falciparum is dependent on pantothenate (vitamin B5), a precursor of the fundamental enzyme cofactor coenzyme A. CJ-15,801, an enamide analogue of pantothenate isolated from the fungus Seimatosp
COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATION AND LIPID DISORDERS
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, (2015/03/04)
The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing inflammation and lipid disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of hypertriglyceridemia, steatohepatitis, cystinosis and inflammatory diseases.
Fast and flexible synthesis of pantothenic acid and CJ-15,801
Sewell, Alan L.,Villa, Mathew V. J.,Matheson, Mhairi,Whittingham, William G.,Marquez, Rodolfo
, p. 800 - 803 (2011/04/25)
The fast and efficient syntheses of pantothenic acid and the antiparasitic agent CJ-15,801 have been achieved starting from a common imide unit through the selective manipulation of enamide intermediates.
