126535-92-0Relevant articles and documents
Incorporation of the unusual Cα-fluoroalkylamino acids into cyclopeptides: Synthesis of arginine-glycine-aspartate (RGD) analogues and study of their conformational and biological behavior
Dal Pozzo, Alma,Ni, Minghong,Muzi, Laura,De Castiglione, Roberto,Mondelli, Rosanna,Mazzini, Stefania,Penco, Sergio,Pisano, Claudio,Castorina, Massimo,Giannini, Giuseppe
, p. 1808 - 1817 (2007/10/03)
A series of six arginine-glycine-aspartate (RGD) cyclopeptide analogues containing a Cα-di- or trifluoromethylamino acid (α-Dfm or α-TfmAaa) at different positions of the ring were synthesized. All peptides were obtained in two diastereomeric f
The "Non-Oxidative" Chloro-Pummerer Reaction: Novel stereospecific entry to vicinal chloroamines and aziridines
Volonterio, Alessandro,Bravo, Pierfrancesco,Panzeri, Walter,Pesenti, Cristina,Zanda, Matteo
, p. 3336 - 3340 (2007/10/03)
This article describes a new, useful synthetic tool, the "Non-Oxidative" Chloro-Pummerer Reaction (NOCPR), which allows for the use of enantiomerically pure α-Li alkylsulfoxides as chiral α-chloroalkyl carbanions with N-protected imines. In this reaction the sulfinyl group of N-alkoxycarbonyl-β-sulfinylamines derived from aryl-, fluoroalkyl- and alkylimines is displaced by a chlorine atom in a one-pot reaction with clean stereoinversion at carbon. Several 1,2-chloroamines produced via NOCPR were transformed into the corresponding aziridines. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
New Synthetic Pathways to 3,3,3-Trifluoroalanine, 2-Deutero-3,3,3-trifluoroalanine and their Derivatives
Burger, Klaus,Hoess, Eva,Gaa, Karl,Sewald, Norbert,Schierlinger, Christian
, p. 361 - 384 (2007/10/02)
New synthetic pathways to 3,3,3-trifluoroalanine, 2-deutero-3,3,3-trifluoroalanine, their esters, amides, and thioamides are described, starting from hexafluoroacetone, and trifluoropyruvates, respectively.
