126535-86-2Relevant articles and documents
A Broad Substrate Scope of Aza-Friedel-Crafts Alkylation for the Synthesis of Quaternary α-Amino Esters
Zhao, Guangkuan,Samanta, Shyam S.,Michieletto, Jessica,Roche, Stéphane P.
, p. 5822 - 5827 (2020)
A versatile synthetic protocol of aza-Friedel-Crafts alkylation has been developed for the synthesis of quaternary α-amino esters. This operationally simple alkylation proceeds under ambient conditions with high efficiency, regioselectivity, and an exceptionally broad scope of arene nucleophiles. A key feature of this alkylation is the role associated with the silver(I) salt counteranions liberated during the reaction. Taking advantage of a phase-transfer counteranion/Br?nsted acid pair mechanism, we also report a catalytic enantioselective example of the reaction.
Incorporation of the unusual Cα-fluoroalkylamino acids into cyclopeptides: Synthesis of arginine-glycine-aspartate (RGD) analogues and study of their conformational and biological behavior
Dal Pozzo, Alma,Ni, Minghong,Muzi, Laura,De Castiglione, Roberto,Mondelli, Rosanna,Mazzini, Stefania,Penco, Sergio,Pisano, Claudio,Castorina, Massimo,Giannini, Giuseppe
, p. 1808 - 1817 (2007/10/03)
A series of six arginine-glycine-aspartate (RGD) cyclopeptide analogues containing a Cα-di- or trifluoromethylamino acid (α-Dfm or α-TfmAaa) at different positions of the ring were synthesized. All peptides were obtained in two diastereomeric f
