1265359-46-3Relevant academic research and scientific papers
Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656)
Li, Xianfeng,Hernandez, Vincent,Rock, Fernando L.,Choi, Wai,Mak, Yvonne S. L.,Mohan, Manisha,Mao, Weimin,Zhou, Yasheen,Easom, Eric E.,Plattner, Jacob J.,Zou, Wuxin,Pérez-Herrán, Esther,Giordano, Ilaria,Mendoza-Losana, Alfonso,Alemparte, Carlos,Rullas, Joaquín,Angulo-Barturen, I?igo,Crouch, Sabrinia,Ortega, Fátima,Barros, David,Alley
, p. 8011 - 8026 (2017/10/18)
There is an urgent need to develop new and safer antitubercular agents that possess a novel mode of action. We synthesized and evaluated a novel series of 3-aminomethyl 4-halogen benzoxaboroles as Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (L
1 -HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS
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, (2014/10/03)
Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. The claimed compounds are described by the following Markush formula:A typical example for a compound according to above formula is: A typical example for a compound according to above formula is:
TRISUBSTITUTED BORON-CONTAINING MOLECULES
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, (2011/02/24)
This invention largely relates to 3,4,6-trisubstituted benzoxaborole compounds, and their use for treating bacterial infections.
