82477-61-0

Basic information

• Product Name: 2-CHLORO-4,6-DIMEHOXYBENZALDEHYDE
• Synonyms: CHEMBRDG-BB 5373668;2-CHLORO-4,6-DIMEHOXYBENZALDEHYDE;2-Chloro-4,6-dimethoxybenzaldehyde;2-chloro-4,6-dimethoxybenzaldehyde(SALTDATA: FREE)
• CAS NO: 82477-61-0
• Molecular Formula: C₉H₉ClO₃
• Molecular Weight: 200.62
• Mol File: 82477-61-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 79-80℃
• Boiling Point: 326 °C at 760 mmHg
• Flash Point: 144.9 °C
• Appearance: /
• Density: 1.245±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.000222mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-CHLORO-4,6-DIMEHOXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4,6-DIMEHOXYBENZALDEHYDE(82477-61-0)
• EPA Substance Registry System: 2-CHLORO-4,6-DIMEHOXYBENZALDEHYDE(82477-61-0)

Safety Data

• Hazardous Substances Data: 82477-61-0(Hazardous Substances Data)

Usage

General Description

2-Chloro-4,6-dimethoxybenzaldehyde is a chemical compound with the molecular formula C9H9ClO3. It is a white to pale yellow crystalline solid that is used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is also used in organic reactions as a reagent. 2-CHLORO-4,6-DIMEHOXYBENZALDEHYDE is known for its aromatic properties and is commonly used in the synthesis of heterocyclic compounds. It is important to handle and store this compound with caution as it can be harmful if ingested, inhaled, or in contact with skin.

InChI:InChI=1/C9H9ClO3/c1-12-6-3-8(10)7(5-11)9(4-6)13-2/h3-5H,1-2H3

Upstream product

• 82485-84-5 6-amino-5-chloro-1,3-dimethoxybenzene 
• 637-62-7 p-benzoquinone oxime 
• 7051-16-3 1-chloro-3,5-dimethoxybenzene 
• 93-61-8 N-methyl-N-phenylformamide 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1200131-12-9 1-(2-chloro-4,6-dimethoxybenzyl)piperidine 
• 1200131-14-1 trifluoromethanesulfonic acid 3-chloro-5-methoxy-4-piperidin-1-ylmethylphenyl ester 
• 1200131-13-0 3-chloro-5-methoxy-4-piperidin-1-ylmethylphenol 
• 1383923-03-2 (2Z)-2-(6-chloro-2,4-dimethoxybenzylidene)-4H-furo[3,2-c]chromene-3,4(2H)-dione 
• 1265359-46-3 2-chloro-4-(tetrahydro-2H-pyran-2-yloxy)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 
• 1265359-44-1 3-chloro-2-formyl-5-((tetrahydro-2H-pyran-2-yl)oxy)phenyl trifluoromethane sulfonate 
• 1265359-42-9 2-chloro-6-hydroxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde 
• 116475-68-4 2-chloro-6-hydroxy-4-methoxybenzaldehyde 
• 849920-01-0 1-(2-chloro-4,6-dimethoxyphenyl)-2-nitro-1-propene 
• 82477-60-9 2-chloro-4,6-dimethoxybenzoic acid 

Relevant articles and documents

1 -HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS

Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. The claimed compounds are described by the following Markush formula:A typical example for a compound according to above formula is: A typical example for a compound according to above formula is:

Sulfur-substituted α-alkyl phenethylamines as selective and reversible MAO-A inhibitors: Biological activities, CoMFA analysis, and active site modeling

A series of phenethylamine derivatives with various ring substituents and with or without N-methyl and/or C-α methyl or ethyl groups was synthesized and assayed for their ability reversibly to inhibit monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). Several compounds showed potent and selective MAO-A inhibitory activity (IC50 in the submicromolar range) but none showed appreciable activity toward MAO-B. A three-dimensional quantitative structure-activity relationship study for MAO-A inhibition was performed on the series using comparative molecular field analysis (CoMFA). The resulting model gave a cross-validated q2 of 0.72 and showed that in this series of compounds steric properties of the substituents were more important than electrostatic effects. Molecular modeling based on the recently published crystal structure of inhibitor-bound MAO-A provided detailed evidence for specific interactions of the ligands with the enzyme, supported by previous references and consistent with results from the CoMFA. On the basis of these results, structural determinants for selectivity of substituted amphetamines for MAO-A are discussed.