1265431-53-5

Basic information

• Product Name: (R)-ethyl 2-{[(benzyloxy)carbonyl]amino}-3,3,3-trifluoro-2-(1H-indol-3-yl)propanoate
• CAS NO: 1265431-53-5
• Molecular Weight: 420.388
• Mol File: 1265431-53-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-ethyl 2-{[(benzyloxy)carbonyl]amino}-3,3,3-trifluoro-2-(1H-indol-3-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-ethyl 2-{[(benzyloxy)carbonyl]amino}-3,3,3-trifluoro-2-(1H-indol-3-yl)propanoate(1265431-53-5)
• EPA Substance Registry System: (R)-ethyl 2-{[(benzyloxy)carbonyl]amino}-3,3,3-trifluoro-2-(1H-indol-3-yl)propanoate(1265431-53-5)

Safety Data

• Hazardous Substances Data: 1265431-53-5(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 13081-18-0 ethyl-3,3,3-trifluoropyruvate 
• 621-84-1 O-benzyl carbamate 
• 126535-92-0 ethyl 2-{[(benzyloxy)carbonyl]imino}-3,3,3-trifluoropropanoate 

Relevant articles and documents

A Broad Substrate Scope of Aza-Friedel-Crafts Alkylation for the Synthesis of Quaternary α-Amino Esters

A versatile synthetic protocol of aza-Friedel-Crafts alkylation has been developed for the synthesis of quaternary α-amino esters. This operationally simple alkylation proceeds under ambient conditions with high efficiency, regioselectivity, and an exceptionally broad scope of arene nucleophiles. A key feature of this alkylation is the role associated with the silver(I) salt counteranions liberated during the reaction. Taking advantage of a phase-transfer counteranion/Br?nsted acid pair mechanism, we also report a catalytic enantioselective example of the reaction.