126545-16-2Relevant academic research and scientific papers
Highly E-selective synthesis of α,β-unsaturated amides from N-2- methoxyphenyl aldimines via lithium ynolates
Shindo, Mitsuru,Oya, Soichiro,Murakami, Ryoko,Sato, Yusuke,Shishido, Kozo
, p. 5947 - 5950 (2000)
Lithium ynolates reacted with N-2-methoxyphenyl (OMP) aldimines to afford α,β-unsaturated amides in excellent E-selectivity via a retro- Mannich reaction of the 2:1 adducts (β-lactams), followed by cleavage of the β-lactam enolates. (C) 2000 Elsevier Science Ltd.
An investigation into the structure-activity relationships associated with the systematic modification of the β2-adrenoceptor agonist indacaterol
Beattie, David,Beer, David,Bradley, Michelle E.,Bruce, Ian,Charlton, Steven J.,Cuenoud, Bernard M.,Fairhurst, Robin A.,Farr, David,Fozard, John R.,Janus, Diana,Rosethorne, Elizabeth M.,Sandham, David A.,Sykes, David A.,Trifilieff, Alexandre,Turner, Katharine L.,Wissler, Elke
, p. 6280 - 6285 (2012/10/30)
The synthesis of a series of indacaterol analogues in which each of the three structural regions of indacaterol are modified in a systematic manner is described. Evaluation of the affinity of these analogues for the β2-adrenoceptor identified t
AlCl3-mediated Regioselective Migration of a Methoxy Group of N-Methoxy-N-phenylamides to the ortho Position of the Phenyl Ring
Kikugawa, Yasuo,Shimada, Masahiro
, p. 1450 - 1451 (2007/10/02)
AlCl3-mediated decomposition of N-methoxy-N-phenylamides in dichloroethane leads to regioselective intramolecular migration of the methoxy group from the nitrogen to the ortho position of the phenyl ring via a tight ion pair intermediate.
