1895-97-2

Basic information

• Product Name: α-Methylcinnamic acid
• Synonyms: (E)-2-Methyl-3-phenylpropenoic acid;(E)-3-Phenylmethacrylic acid;(E)-α-Benzylidenepropionic acid;trans-α-Methylcinnamic acid;α-Methyl-trans-cinnamic acid
• CAS NO: 1895-97-2
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.1852
• Mol File: 1895-97-2.mol
• Article Data: 50

Chemical Properties

• Melting Point: 80 °C
• Boiling Point: 248.88°C (rough estimate)
• Appearance: /
• Density: 1.0613 (rough estimate)
• Refractive Index: 1.5120 (estimate)
• Solubility: soluble in Methanol
• Water Solubility: 3.5g/L(25 oC)
• CAS DataBase Reference: α-Methylcinnamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: α-Methylcinnamic acid(1895-97-2)
• EPA Substance Registry System: α-Methylcinnamic acid(1895-97-2)

Safety Data

• Hazardous Substances Data: 1895-97-2(Hazardous Substances Data)

Usage

General Description

α-Methylcinnamic acid, also known as 2-Methyl-3-phenyl-2-propenoic acid, is a synthetic, crystalline chemical compound that belongs to the class of cinnamic acids. It is derived from cinnamic acid and has a molecular formula of C10H10O2. α-Methylcinnamic acid is commonly used as a flavor and fragrance enhancer in various products such as cosmetics, soaps, and perfumes. It is also used in the pharmaceutical industry as an intermediate for the synthesis of active pharmaceutical ingredients. Furthermore, α-Methylcinnamic acid has been studied for its potential antioxidant and anti-inflammatory properties, making it a subject of interest in the field of medicinal chemistry.

Upstream product

• 42968-14-9 (E)-3-methyl-4-phenyl-3-buten-2-one 
• 24744-96-5 ethyl 3-hydroxy-2-methyl-3-phenylpropionate 
• 100-52-7 benzaldehyde 
• 123-62-6 propionic acid anhydride 
• 39934-05-9 endo-1,5-dimethyl-2,3,4,6,7-pentaphenyltricyclo<3.2.1.0^2,4>-6-octen-8-one 
• 598-72-1 2-Bromopropionic acid 
• 15174-47-7 α-methyl-trans-cinnamaldehyde 
• 598-78-7 (R,S)-2-chloropropionic acid 
• 105-58-8 Diethyl carbonate 
• 124957-36-4 Methyl 3-acetoxy-2-methylene-3-phenylpropanoate 
• 110-86-1 pyridine 
• 7719-09-7 thionyl chloride 
• 100-34-5 benzene diazonium chloride 
• 2327-99-3 1-phenylpropadiene 

Downstream Products

• 15250-29-0 (Z)-2-methyl-3-phenylprop-2-enoic acid 
• 1009-67-2 2-methyl-3-phenylpropanoic acid 
• 66482-10-8 (2RS:3SR)-2,3-dibromo-2-methyl-3-phenyl-propionic acid 
• 7042-33-3 ethyl (E)-2-methyl-3-phenyl-2-propenoate 
• 92593-15-2 selenophenyl α-methylcinnamate 
• 25547-51-7 trans-2-methyl-3-phenyloxiranecarboxylic acid 
• 70841-95-1 2-methyl-3-phenylpropanoic acid-α,β-d₂ 
• 71001-35-9 (2-bromoprop-1-en-1-yl)benzene 
• 35086-87-4 (E)-2-methyl-3-phenylacryloyl chloride 
• 33066-18-1 (E)-α-Methylzimtsaeureazid 
• 14367-67-0 2-methyl-3-phenylpropionic acid 
• 1009-67-2 2-methyl-3-phenylpropionic acid 
• 98831-01-7 (2E)-tert-butyl 2-methyl-3-phenylprop-2-enoate 
• 22946-43-6 (E)-methyl-2-methyl-3-phenylacrylate 

Relevant articles and documents

Method for synthesizing alkyl olefin through coupling of double-bond carbon-hydrogen bond and saturated carbon-hydrogen bond

The invention discloses a method for synthesizing alkyl olefin through coupling of a double-bond carbon-hydrogen bond and a saturated carbon-hydrogen bond. According to to the method, one-pot reactionis implemented on olefin and sulfoxide in the presence of ferric salt and hydrogen peroxide to generate alkyl olefin; in the method, sulfoxide is simultaneously used as a hydrocarbylation reagent anda solvent of olefin, and a reaction product is alkyl olefin from sulfoxide alkyl coupled with olefin carbon atoms, so that an olefin carbon chain is increased; the reaction conditions are mild, the selectivity is good, the yield is high, and industrial production is facilitated.

Direct 3-Acylation of Indolizines by Carboxylic Acids for the Practical Synthesis of Red Light-Releasable Caged Carboxylic Acids

To enhance the practicality of photouncaging system using 3-acyl-2-methoxyindolizines, direct acylation of indolizines with carboxylic acids was developed using condensation reagents, generally used for peptide coupling. This method allowed for caging a broad range of carboxylic acids with indolizines. The method enabled a facile synthesis of water-soluble caged bioactive carboxylic acids having an intramolecular photosensitizer. The efficient release of carboxylic acids from the synthesized caged compounds upon red light irradiation was confirmed in neutral buffered solutions.

Method for preparing alpha, beta-unsaturated carboxylic acid compound

The invention discloses a method for preparing an alpha, beta-unsaturated carboxylic acid compound, which comprises the following steps: 1) in an atmosphere containing carbon dioxide, heating and reacting a mixture containing hydrosilane and a copper catalyst to obtain a system I; and 2) adding a raw material containing alkyne and a nickel catalyst into the system I in the step 1), and heating to react. The method has the advantages of simple, easily available, cheap and stable raw materials, common, easily available and stable catalyst, mild reaction conditions, simple post-treatment, high yield and the like.