126559-72-6

Upstream product

• 126559-80-6 (2RS,3SR,5SR)-3,5-bis(t-butyldimethylsiloxy)-2-(phenylthiomethyl)cyclohexanone 
• 126559-80-6 (2RS,3RS,5RS)-3,5-bis(t-butyldimethylsiloxy)-2-(phenylthiomethyl)cyclohexanone 
• 126559-74-8 (+/-)-ethyl (E)-3,5-dihydroxy-7-(phenylthio)-hept-6-enoate 
• 126559-79-3 (+/-)-Se-phenyl (E)-3,5-anti-bis(t-butyldimethylsiloxy)-7-(phenylthio)hept-6-eneselenoate 
• 126559-78-2 (+/-)-(E)-3,5-anti-bis(t-butyldimethylsiloxy)-7-(phenylthio)hept-6-enoic acid 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 126559-76-0 (+/-)-ethyl (E)-3,5-anti-bis(t-butyldimethylsiloxy)-7-(phenylthio)-hept-6-enoate 
• 126559-73-7 (+/-)-ethyl (E)-5-hydroxy-3-oxo-7-(phenylthio)-hept-6-enoate 
• 137718-83-3 trans-2-bromo-4-(tert-butyldimethylsiloxy)cyclohexanone 

Relevant academic research and scientific papers

Acyl Radical Cyclizations in Synthesis. Part 3. Synthesis of (+/-)-trans-3,5-Bis(t-butyldimethylsiloxy)-2-Methylenecyclohexanone, an 'A' Ring Model for 1α,25-Dihydroxyvitamin D3

A concise synthesis of (+/-)-trans-3,5-bis(t-butyldimethylsiloxy)-2-methylenecyclohexanone has been developed.The synthesis proceeds in seven steps from ethyl acetoacetate and involves a highly efficient acyl radical cyclization to construct the six-membered ring.