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Siomycin A, a macrocyclic antibiotic discovered in 1969, possesses potent and selective antibacterial activity. It is a powerful inhibitor of the oncogenic transcription factor, FoxM1, which plays a crucial role in the regulation of cell growth and proliferation. By reducing the transcription activity of FoxM1, siomycin A leads to the downregulation of protein and mRNA levels of FoxM1 and its downstream genes, such as Cdc25B, survivin, and CENPB. In vitro, siomycin A has been shown to inhibit FoxM1-induced cell growth on soft agar and selectively target transformed cells without affecting normal cells.

12656-09-6

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12656-09-6 Usage

Uses

Used in Anticancer Applications:
Siomycin A is used as an anticancer agent for its ability to inhibit the oncogenic transcription factor, FoxM1. By targeting FoxM1, siomycin A can potentially disrupt the growth and proliferation of cancer cells, making it a promising candidate for the development of novel cancer therapies.
Used in Antibacterial Applications:
Siomycin A is used as an antibiotic for its potent and selective antibacterial activity. This characteristic makes it a valuable tool in the fight against bacterial infections, particularly those caused by drug-resistant strains.
Used in Pharmaceutical Research:
Siomycin A is used as a research tool for studying the role of FoxM1 in cell growth and proliferation. Its ability to inhibit FoxM1 makes it a valuable compound for understanding the molecular mechanisms underlying cancer development and identifying potential therapeutic targets.
Used in Drug Development:
Siomycin A is used as a lead compound in the development of new drugs targeting FoxM1 and other related pathways. Its unique properties and selectivity make it an attractive candidate for the design of novel therapeutic agents with potential applications in cancer treatment and other diseases associated with abnormal cell growth.

Check Digit Verification of cas no

The CAS Registry Mumber 12656-09-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,2,6,5 and 6 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 12656-09:
(7*1)+(6*2)+(5*6)+(4*5)+(3*6)+(2*0)+(1*9)=96
96 % 10 = 6
So 12656-09-6 is a valid CAS Registry Number.
InChI:InChI=1/C71H81N19O18S5/c1-14-37-64-83-45(22-109-64)61(103)89-52(70(13,107)34(12)93)67-85-44(23-112-67)59(101)88-49-33(11)108-68(106)39-17-36(31(9)91)35-15-16-38(51(94)50(35)80-39)79-47(25(2)3)62(104)77-29(7)56(98)74-27(5)55(97)75-30(8)57(99)90-71(69-86-46(24-113-69)60(102)87-48(32(10)92)63(105)81-37)18-40(42-20-111-66(49)82-42)78-41(19-71)65-84-43(21-110-65)58(100)76-28(6)54(96)73-26(4)53(72)95/h14-17,20-21,23-25,30-34,38,40,45,47-49,51-52,79,91-94,107H,4-7,18-19,22H2,1-3,8-13H3,(H2,72,95)(H,73,96)(H,74,98)(H,75,97)(H,76,100)(H,77,104)(H,81,105)(H,87,102)(H,88,101)(H,89,103)(H,90,99)/b37-14+

12656-09-6 Well-known Company Product Price

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  • Sigma

  • (S6076)  Siomycin A  from Streptomyces sioyaensis, ≥98% (HPLC)

  • 12656-09-6

  • S6076-500UG

  • 4,947.93CNY

  • Detail

12656-09-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Thiostrepton, 1-valine-2-(2,3-didehydroalanine)-

1.2 Other means of identification

Product number -
Other names siomycin A

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:12656-09-6 SDS

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