1265624-86-9

Upstream product

• 1265624-85-8 cyano(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)acetic acid ethyl ester 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 60356-11-8 cyano(1,4-dioxaspiro[4.5]dec-8-ylidene)acetic acid ethyl ester 

Downstream Products

• 1265624-89-2 C₁₆H₂₀O₄ 
• 1265624-87-0 (4-oxo-1-phenylcyclohexyl)acetonitrile 
• 1616922-12-3 6-(4,4-difluoro-1-phenylcyclohexylmethyl)-9-hydroxy-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 
• 1616924-43-6 N-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)acetamidine 
• 1616924-44-7 (Z)-(1-amino-2-{8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl}ethylidene)amino acetate 
• 1616924-46-9 2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)acetamidine acetic acid salt 
• 1616924-47-0 5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester 
• 1616924-48-1 5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid 
• 1616924-49-2 5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide 
• 1616924-50-5 5-benzyloxy-6-hydroxy-2-(4-oxo-1-phenylcyclohexylmethyl)pyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide 
• 1616924-51-6 9-benzyloxy-2-isopropyl-6-(4-oxo-1-phenylcyclohexylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 
• 1616924-52-7 9-benzyloxy-6-(4,4-difluoro-1-phenylcyclohexylmethyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 

Relevant academic research and scientific papers

PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors

The synthesis and SAR of a series of 4,4-disubstituted cyclohexylbenzamide inhibitors of 11β-HSD1 are described. Optimization rapidly led to potent, highly selective, and orally bioavailable inhibitors demonstrating efficacy in both rat and non-human primate ex vivo pharmacodynamic models.