1265634-73-8

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 1265637-60-2 tert-butyl 4-chloro-3-((4-methoxybenzylamino)methyl) pyridin-2-ylcarbamate 
• 868736-42-9 tert-butyl N-(4-chloro-3-formylpyridin-2-yl)carbamate 
• 130721-78-7 tert-butyl (4-chloropyridin-2-yl) carbamate 
• 1265637-61-3 4-chloro-3-((4-methoxybenzylamino)methyl)pyridin-2-amine 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 1265635-29-7 5-(4-amino-2-fluorophenoxy)-3-(4-methoxybenzyl)-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one 
• 1265635-97-9 5-(2,4-difluorophenyl)-3-(4-methoxybenzyl)-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one 
• 1265635-71-9 5-[(5-chloro-1,3-benzodioxol-4-yl)amino]-3-(4-methoxybenzyl)-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one 
• 1265635-32-2 2,5-dichloro-N-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)nicotinamide 
• 1265635-33-3 N-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 
• 1265635-34-4 2-fluoro-N-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)benzenesulfonamide 
• 1265635-35-5 N-(3-chlorophenyl)-N'-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)urea 
• 1309922-44-8 3-fluoro-N-(6-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}-1-methyl-1H-indazol-3-yl)benzamide 
• 1422264-05-8 1-phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid{3-fluoro-4-[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yloxy]phenyl}amide 
• 1422264-04-7 1-phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid[3-fluoro-4-(2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yloxy)phenyl]amide 
• 1265637-53-3 3-(4-Methoxy-benzyl)-5-(4-quinoxalin-2-yl-phenoxy)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidin-2-one 
• 1265637-52-2 1-(4-fluoro-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid [1-methyl-6-(2-oxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidin-5-yloxy)-1H-indazol-3-yl]-amide 
• 1265637-51-1 1-(4-fluoro-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid {6-[3-(4-methoxy-benzyl)-2-oxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidin-5-yloxy]-1-methyl-1H-indazol-3-yl}-amide 
• 1265637-49-7 5-(3-Amino-1-methyl-1H-indazol-6-yloxy)-3-(4-methoxy-benzyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidin-2-one 

Relevant academic research and scientific papers

PYRIDO-PYRIMIDINE DERIVATIVES

Compounds of the formula I in which Het, R3 and R4 have the meanings indicated in Claim 1, are inhibitors of RON and can be employed, for the treatment of cancer.

NOVEL BICYCLIC UREA COMPOUNDS

The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.