126583-98-0

Upstream product

• 30389-18-5 1-Ethynylcyclohexylamine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 143256-97-7 N-(1-{3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-bicyclo[2.2.1]hept-2-ylethynyl}-cyclohexyl)-4-methyl-benzenesulfonamide 
• 139372-16-0 N-{1-[(Z)-2-(Dimethyl-phenyl-silanyl)-1-formyl-vinyl]-cyclohexyl}-4-methyl-benzenesulfonamide 
• 139372-11-5 3-[1-(Dimethyl-phenyl-silanyl)-meth-(Z)-ylidene]-1-(toluene-4-sulfonyl)-1-aza-spiro[3.5]nonan-2-one 
• 126583-96-8 N-(1-Acetyl-cyclohexyl)-4-methyl-benzenesulfonamide 
• 491879-40-4 N-(1-ethynylcyclohexyl)-4-methyl-N-(2-methylallyl)benzenesulfonamide 
• 1646192-70-2 4-methyl-N-(1-(2-oxoethyl)cyclohexyl)benzenesulfonamide 
• 1206-41-3 N-(2-methylallyl)-4-toluenesulfonamide 

Relevant academic research and scientific papers

Mechanistic Insights into the Ru(II)-Catalyzed Intramolecular Formal [3 + 2] Cycloaddition of (E)-1,6-Enynes

Design of a unique reaction pathway in transition-metal-catalyzed 1,6-enynes cyclization to construct valuable synthetic motifs is a significant challenge in organic chemistry. Herein, we report a Ru(II)-catalyzed formal [3 + 2] cycloaddition as an efficient method to prepare unprecedented bicyclo[3.3.0]octenes from readily available (E)-1,6-enynes. Mechanistic studies based on the deuterium labeling experiments and the DFT calculation disclose a reasonable mechanistic pathway, where a ruthenacyclopentene generated by an ene-yne oxidative cyclization undergoes a sequential ?-hydride elimination and intramolecular hydroruthenation to form a ruthenacyclohexene, producing the desirable bicyclo[3.3.0]octenes.

Ruthenium-Catalyzed Hydroalkynylative Cyclization of 1,6-Enynes Induced by Substituent Effects

The ruthenium-catalyzed 1,6-enyne cyclization in the presence of bulky substituted terminal alkyne proceeds smoothly at room temperature to afford highly substituted five-membered cyclic compounds featuring a 1,5-enyne motif. Deuterium-labeling experiment

Cyclobutene formation in PtCl2-catalyzed cycloisomerizations of heteroatom-tethered 1,6-enynes

Aza(oxa)bicyclo[3.2.0]heptenes are accessed through the PtCl 2-catalyzed cycloisomerizations of heteroatom-tethered 1,6-enynes featuring a terminal alkyne and amide as the solvent. It is shown that the weak coordinating properties of the solven

Effects of substituents on the multiple bonds on ring-closing metathesis of enynes

In ring-closing metathesis (RCM) reactions of enynes, the substituents on the multiple bonds are quite important. Although RCM of an enyne having a monosubstituted alkene proceeds smoothly using the first-generation ruthenium-carbene complex 1a, that of a