126587-48-2

Upstream product

• 102308-32-7 (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 123751-10-0 N-(tert-butoxycarbonyl)-2,2-dimethyl-4(R)-<2'-carboxymethylethenyl>-oxazolidine 
• 95715-86-9 (S)-2,2-dimethyl-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester 
• 2766-43-0 N-tert-butyloxycarbonyl-L-serine methyl ester 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 3262-72-4 (S)-N-(tert-butoxycarbonyl)serine 
• 831-91-4 Benzyl phenyl sulfide 
• 126587-39-1 (2Z,4R)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-penten-5-olide 
• 126587-40-4 [(3R,4S)-6-Oxo-4-(phenyl-phenylsulfanyl-methyl)-tetrahydro-pyran-3-yl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Acyclic analogs of kainoids: Their syntheses and depolarizing activities

Four stereoisomers of the β-benzylglutamic acids were synthesized by the Michael addition of benzylphenylsulfide to protected (4S)- and (4R)-4-amino-2-penten-5-olide and to protected (2S)- and (2R)-3-dehydro-2-hydroxymethyl-5-pyrrolidone. The β-methallyl- and β-isobutylglutamic acids were also synthesized in a similar manner. The depolarizing activities of these synthesized compounds were observed.

SYNTHESIS OF ACYCLIC ANALOGUES OF KAINOIDS AND NEUROEXCITATORY ACTIVITY

Four configurational isomers of 3-benzylglutamic acid, acyclic analogues of kainoids were synthesized to examine their structure-activity relationship.