1265895-96-2Relevant academic research and scientific papers
Molecular design, synthesis, and structure-activity relationships leading to the potent and selective p56lck inhibitor BMS-243117
Das, Jagabandhu,Lin, James,Moquin, Robert V.,Shen, Zhongqi,Spergel, Steven H.,Wityak, John,Doweyko, Arthur M.,DeFex, Henry F.,Fang, Qiong,Pang, Suhong,Pitt, Sidney,Shen, Ding Ren,Schieven, Gary L.,Barrish, Joel C.
, p. 2145 - 2149 (2003)
A series of structurally novel benzothiazole based small molecule inhibitors of p56lck were prepared to elucidate their structure-activity relationships (SARs), selectivity and cell activity in the T-cell proliferation assay. BMS-243117 (compound 2) is identified as a potent, and selective Lck inhibitor with good cellular activity (IC50=1.1 μM) against T-cell proliferation.
