Bioorganic and Medicinal Chemistry Letters p. 2145 - 2149 (2003)
Update date:2022-08-02
Topics:
Das, Jagabandhu
Lin, James
Moquin, Robert V.
Shen, Zhongqi
Spergel, Steven H.
Wityak, John
Doweyko, Arthur M.
DeFex, Henry F.
Fang, Qiong
Pang, Suhong
Pitt, Sidney
Shen, Ding Ren
Schieven, Gary L.
Barrish, Joel C.
A series of structurally novel benzothiazole based small molecule inhibitors of p56lck were prepared to elucidate their structure-activity relationships (SARs), selectivity and cell activity in the T-cell proliferation assay. BMS-243117 (compound 2) is identified as a potent, and selective Lck inhibitor with good cellular activity (IC50=1.1 μM) against T-cell proliferation.
View MoreContact:+86+21-58956006 15800617331
Address:402 Room, 150# Cailun Road, Zhangjiang high tech park, Shanghai
Lyrin Industrial Corporation Limited
Contact:86-731-82571800
Address:Rm 2408,Asia Economy International Building,Shaoshan Road South,Yuhua District,Changsha,Hunan,China
Beijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)
Contact:010-52876516
Address:tongzhoubeiyuan
Nanjing Chemlin Chemical Co., Ltd.
website:http://www.echemlin.cn
Contact:+86-25-83697070
Address:Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China
Contact:+44 (0)2036089360-31
Address:Chanceryhouse,Chancery Lan
Doi:10.1016/j.tetlet.2011.01.070
(2011)Doi:10.1039/c0dt01384f
(2011)Doi:10.1007/BF00963028
(1990)Doi:10.1021/ol200347g
(2011)Doi:10.1021/op010012k
(2001)Doi:10.1002/adsc.201000792
(2011)