1265917-57-4Relevant articles and documents
Stereocontrolled construction of quaternary stereocenters by inter- and intramolecular nitro-michael additions catalyzed by bifunctional thioureas
Manzano, Ruben,Andres, Jose M.,Muruzabal, Maria D.,Pedrosa, Rafael
experimental part, p. 3364 - 3372 (2011/03/17)
A highly diastereo- and enantioselective conjugate addition of β-keto esters to nitroolefins, catalyzed by a chiral thiourea prepared from L-valine is described. The formation of two contiguous tertiary and quaternary stereocenters occurs in high yield an