1266098-30-9

Basic information

• Product Name: 2-chloro-6-trimethylsilylamino-9-[3,5-di-O-(4-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-purine
• Synonyms: 2-chloro-6-trimethylsilylamino-9-[3,5-di-O-(4-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-purine
• CAS NO: 1266098-30-9
• Molecular Weight: 634.978
• Mol File: 1266098-30-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-chloro-6-trimethylsilylamino-9-[3,5-di-O-(4-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-purine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6-trimethylsilylamino-9-[3,5-di-O-(4-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-purine(1266098-30-9)
• EPA Substance Registry System: 2-chloro-6-trimethylsilylamino-9-[3,5-di-O-(4-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-purine(1266098-30-9)

Safety Data

• Hazardous Substances Data: 1266098-30-9(Hazardous Substances Data)

Upstream product

• 25561-30-2 N,O-Bis(trimethylsilyl)trifluoroacetamide 
• 1839-18-5 2-chloroadenine 

Downstream Products

• 4291-63-8 2-chloro-2'-deoxyadenosine 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF CLADRIBINE

A process for the preparation of cladribine of API grade is provided by direct coupling of O-protected 2-deoxy-ribofuranose with silylated 2-chloroadenine followed by deprotection of the resultant protected nucleoside in a separate step and then a purification step. Following the coupling, the desired N-9-glycosylated β-anomer of the nucleoside is directly isolated as a solid from the coupling reaction mixture by filtration in relatively high purity and yield, and it does not require purification.