1266332-65-3Relevant academic research and scientific papers
The use of Co-crystals for the determination of absolute stereochemistry: An alternative to salt formation
Eccles, Kevin S.,Deasy, Rebecca E.,Fabian, Laszlo,Maguire, Anita R.,Lawrence, Simon E.
experimental part, p. 1159 - 1162 (2011/05/05)
Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.
